Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 37720..38228 Replicon plasmid unnamed3
Accession NZ_CP092579
Organism Enterococcus faecalis strain VRE-WC031

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8B3RS79
Locus tag MKI49_RS16130 Protein ID WP_010717545.1
Coordinates 37959..38228 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B3RRA5
Locus tag MKI49_RS16125 Protein ID WP_010717544.1
Coordinates 37720..37974 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI49_RS16100 (MKI49_003198) 33816..34340 + 525 WP_010717541.1 hypothetical protein -
MKI49_RS16105 (MKI49_003199) 34355..35179 + 825 WP_010717542.1 hypothetical protein -
MKI49_RS16110 (MKI49_003200) 35597..35860 + 264 WP_002358468.1 hypothetical protein -
MKI49_RS16115 (MKI49_003201) 35853..36410 + 558 WP_002358242.1 hypothetical protein -
MKI49_RS16120 (MKI49_003202) 36413..37648 + 1236 WP_015543650.1 MobP2 family relaxase -
MKI49_RS16125 (MKI49_003203) 37720..37974 + 255 WP_010717544.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI49_RS16130 (MKI49_003204) 37959..38228 + 270 WP_010717545.1 Txe/YoeB family addiction module toxin Toxin
MKI49_RS16135 (MKI49_003205) 38293..39873 + 1581 WP_010717546.1 DUF3991 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - prgB/asc10 1..54685 54685


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10482.29 Da        Isoelectric Point: 10.4617

>T236692 WP_010717545.1 NZ_CP092579:37959-38228 [Enterococcus faecalis]
MGYTIKIKKNARKDLPKLKAAHLNKKFDELVKILKENPYQSPPPYEKLVGLNYLSRRLNIQHRLVYTVDDSSKQVIILSV
WSHYERGMN

Download         Length: 270 bp

>T236692 NZ_LR699570:c756343-755906 [Mycobacterium tuberculosis variant bovis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9623.63 Da        Isoelectric Point: 3.9188

>AT236692 WP_010717544.1 NZ_CP092579:37720-37974 [Enterococcus faecalis]
METITPTNARKNLYGLIKHVVSDSQPVEISNTTNEQESVVVISKSDWNAIQETLYLQNVGVLDRIKQFEEEETEELGEID
WDTL

Download         Length: 255 bp

>AT236692 NZ_LR699570:c756594-756340 [Mycobacterium tuberculosis variant bovis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3RS79

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3RRA5

References