Detailed information of TA system TA236682

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2909100..2909501
• Replicon: chromosome
• Accession: NZ_CP092576
• Organism: Enterococcus faecalis strain VRE-WC031

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: MKI49_RS14450
• Protein ID: WP_002392696.1
• Coordinates: 2909358..2909501 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2909100..2909245 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI49_RS14430 (2904321)	2904321..2905313	+	993	WP_002368503.1	biotin--[acetyl-CoA-carboxylase] ligase	-
MKI49_RS14435 (2905577)	2905577..2906215	-	639	WP_024041656.1	lytic polysaccharide monooxygenase	-
MKI49_RS14440 (2906900)	2906900..2908516	+	1617	WP_002368505.1	phosphatase PAP2/LCP family protein	-
MKI49_RS14445 (2908785)	2908785..2908928	+	144	WP_277813275.1	type I toxin-antitoxin system toxin PepG1	-
- (2908861)	2908861..2909047	-	187	NuclAT_7	-	-
- (2909078)	2909078..2909245	-	168	NuclAT_14	-	-
- (2909100)	2909100..2909245	-	146	NuclAT_9	-	Antitoxin
MKI49_RS14450 (2909358)	2909358..2909501	+	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2909434)	2909434..2909689	-	256	NuclAT_6	-	-
- (2909641)	2909641..2909690	+	50	NuclAT_17	-	-
- (2909475)	2909475..2909691	-	217	NuclAT_13	-	-
MKI49_RS14455 (2909691)	2909691..2912750	-	3060	WP_002368508.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T236682 WP_002392696.1 NZ_CP092576:2909358-2909501 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T236682 NZ_LR699570:677968-678375 [Mycobacterium tuberculosis variant bovis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin

Nucleotide

• Length: 146 bp

>AT236682 NZ_CP092576:c2909245-2909100 [Enterococcus faecalis]
TGTGCTATAATAGCAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAACAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin