Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2908785..2909047 Replicon chromosome
Accession NZ_CP092576
Organism Enterococcus faecalis strain VRE-WC031

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag MKI49_RS14445 Protein ID WP_277813275.1
Coordinates 2908785..2908928 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2908861..2909047 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI49_RS14425 (2903967) 2903967..2904182 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
MKI49_RS14430 (2904321) 2904321..2905313 + 993 WP_002368503.1 biotin--[acetyl-CoA-carboxylase] ligase -
MKI49_RS14435 (2905577) 2905577..2906215 - 639 WP_024041656.1 lytic polysaccharide monooxygenase -
MKI49_RS14440 (2906900) 2906900..2908516 + 1617 WP_002368505.1 phosphatase PAP2/LCP family protein -
MKI49_RS14445 (2908785) 2908785..2908928 + 144 WP_277813275.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2908861) 2908861..2909047 - 187 NuclAT_7 - Antitoxin
- (2909078) 2909078..2909245 - 168 NuclAT_14 - -
- (2909100) 2909100..2909245 - 146 NuclAT_9 - -
MKI49_RS14450 (2909358) 2909358..2909501 + 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
- (2909434) 2909434..2909689 - 256 NuclAT_6 - -
- (2909641) 2909641..2909690 + 50 NuclAT_17 - -
- (2909475) 2909475..2909691 - 217 NuclAT_13 - -
MKI49_RS14455 (2909691) 2909691..2912750 - 3060 WP_002368508.1 WxL domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-47)


Sequences


Toxin        


Download         Length: 48 a.a.        Molecular weight: 5436.60 Da        Isoelectric Point: 10.9857

>T236679 WP_277813275.1 NZ_CP092576:2908785-2908928 [Enterococcus faecalis]
MHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

>T236679 NZ_LR699570:363553-363855 [Mycobacterium tuberculosis variant bovis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 187 bp

>AT236679 NZ_CP092576:c2909047-2908861 [Enterococcus faecalis]
TGTGCTATAATGAAAAGGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTTT
TAGTTACAAAAAATAACCGTACTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References