Detailed information of TA system TA236676

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2834307..2834569
• Replicon: chromosome
• Accession: NZ_CP092576
• Organism: Enterococcus faecalis strain VRE-WC031

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: MKI49_RS14115
• Protein ID: WP_002392696.1
• Coordinates: 2834426..2834569 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2834307..2834493 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI49_RS14100 (2829674)	2829674..2830387	-	714	WP_002354877.1	trehalose operon repressor	-
MKI49_RS16320 (2830490)	2830490..2830624	-	135	WP_002390296.1	hypothetical protein	-
MKI49_RS14105 (2830648)	2830648..2833392	+	2745	WP_002368465.1	glycosyl hydrolase family 65 protein	-
MKI49_RS14110 (2833407)	2833407..2834057	+	651	WP_002368467.1	beta-phosphoglucomutase	-
- (2834112)	2834112..2834251	+	140	NuclAT_10	-	-
- (2834126)	2834126..2834260	+	135	NuclAT_16	-	-
- (2834307)	2834307..2834452	+	146	NuclAT_15	-	-
- (2834307)	2834307..2834493	+	187	NuclAT_8	-	Antitoxin
MKI49_RS14115 (2834426)	2834426..2834569	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
MKI49_RS14120 (2834801)	2834801..2835772	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
MKI49_RS14125 (2835947)	2835947..2836384	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
MKI49_RS14130 (2836517)	2836517..2837071	-	555	WP_002354869.1	Maf family protein	-
MKI49_RS14135 (2837096)	2837096..2839228	-	2133	WP_002368469.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T236676 WP_002392696.1 NZ_CP092576:c2834569-2834426 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T236676 NZ_LR699554:c3431502-3430612 [Paraburkholderia sp. Msb3]
ATGTCCGCTGTTCCATCCGTTACCGCAGATCCACACGCCACGCTCGAAGCGCGCCTTGCGCGTTTCCCGGCGCAGCAGAT
CTGGCTGGCGTCGCAACGCGCGGTGAGCTATCGCGAAGTGGATAGCGCCGACAGCGGCGCGCTGCCGCTCGTGTTGCTGC
ACGGTATCGGTTCGGGCGCGGCGTCGTGGGTGCAGCAGTTCGAAGTGCTTGGCGCGACGCGCCGCGTGCTGGCATGGGAT
GCGCCGGGTTATGGCGCCTCCACGCCGGTCGCGGCCGACTCGCCAACTGCGGCTGACTACGCGAACGTGCTGAAGGAATG
GCTCGACGCGCTCGGCATCGAACGATGCGTGCTGCTTGGGCATTCGCTCGGCGCGATCATAGCCGGCGCGTTTGCCGTGA
TGCATCCGCAGCGCGTGGCCGGGTTGCTGCTGTTGTCGCCGGCTGGCGGTTACGGCGCGGCGTCGGCGGAGGTACGCAAC
ACGAAGCGCGATCAGCGTCTCGCGATGCTGAACGAACTCGGCCCGCAAGGTCTCGCCGAACAACGCAGCACCAATATGTT
GTCCGCTCATGCAAGCGACGAAGCTCGCGCATGGGTGCGCTGGAACATGGCGCGCGTGATCCCGCACGGTTATGCGCAGG
CCACGCATCTGCTCGCCAACGCCGATCTGGCGAGTGACCTCGCGCGCCACCAGGGCCGCATCAACGTGGCCGTCGGTGCC
GACGACACCATTACCACGCCCGAAGCCTGCGAGCGTATCGCGCTGGCCGCGGGCACCAAGTTGCAGGTCGTGCCTCGCGC
GGGGCACGCCGGCTATATCGAAGCACCCGCCGCGTACACCGCGATCATCGACACGTTCTGTCGCACGAGCGACGGACAAC
GGAGCCAATGA

Antitoxin

Nucleotide

• Length: 187 bp

>AT236676 NZ_CP092576:2834307-2834493 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAACCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin