Detailed information of TA system TA236673

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2766256..2766482
• Replicon: chromosome
• Accession: NZ_CP092576
• Organism: Enterococcus faecalis strain VRE-WC031

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MKI49_RS13790
• Protein ID: WP_021164442.1
• Coordinates: 2766381..2766482 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2766256..2766444 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI49_RS13765 (2761876)	2761876..2762829	-	954	WP_002368426.1	siderophore ABC transporter substrate-binding protein	-
MKI49_RS13770 (2762868)	2762868..2763623	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
MKI49_RS13775 (2763620)	2763620..2764585	-	966	WP_002368427.1	iron chelate uptake ABC transporter family permease subunit	-
MKI49_RS13780 (2764582)	2764582..2765529	-	948	WP_002368428.1	iron chelate uptake ABC transporter family permease subunit	-
MKI49_RS13785 (2765714)	2765714..2766166	+	453	WP_002368429.1	YueI family protein	-
- (2766222)	2766222..2766427	+	206	NuclAT_11	-	-
- (2766256)	2766256..2766444	+	189	NuclAT_4	-	Antitoxin
MKI49_RS13790 (2766381)	2766381..2766482	-	102	WP_021164442.1	putative holin-like toxin	Toxin
MKI49_RS13795 (2766673)	2766673..2768943	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
MKI49_RS13800 (2769114)	2769114..2769614	+	501	WP_024041671.1	cysteine hydrolase family protein	-
MKI49_RS13805 (2770013)	2770013..2770909	+	897	WP_002368434.1	YitT family protein	-
MKI49_RS13810 (2770960)	2770960..2771358	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3625.38 Da
• Isoelectric Point: 4.5869

>T236673 WP_021164442.1 NZ_CP092576:c2766482-2766381 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T236673 NZ_LR699553:4299373-4299555 [Paraburkholderia sp. Msb3]
ATGAAAAGTGCCGAGGTTATGAAACTCATTCAAGCGGCTGGTTGGCGGCTGATCCGCATATCGGGCAGCCACCATCATTT
CCGTCACGCGGCAAGAGCCGGTCTCGTGACCATCCCGCATCCGAACAAAGACCTTCCGCCCGGCACGTTGAACAGCATCT
TGAAACAGGCGGGACTGAAATGA

Antitoxin

Nucleotide

• Length: 189 bp

>AT236673 NZ_CP092576:2766256-2766444 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTTATACCAACGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAG
TTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATAC
CGAAAATCAGTAACGCAACAAGGGTTGCA

Structures

Antitoxin