Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 676358..676592 Replicon chromosome
Accession NZ_CP092576
Organism Enterococcus faecalis strain VRE-WC031

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag MKI49_RS03515 Protein ID WP_002355568.1
Coordinates 676358..676474 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 676457..676592 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI49_RS03505 (671796) 671796..674054 + 2259 WP_002363179.1 DNA helicase PcrA -
MKI49_RS03510 (674180) 674180..676210 + 2031 WP_002368024.1 NAD-dependent DNA ligase LigA -
MKI49_RS03515 (676358) 676358..676474 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (676385) 676385..676590 - 206 NuclAT_3 - -
- (676457) 676457..676592 - 136 NuclAT_5 - Antitoxin
- (676457) 676457..676612 - 156 NuclAT_12 - -
MKI49_RS03520 (676792) 676792..677097 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
MKI49_RS03525 (677097) 677097..678566 + 1470 WP_002368026.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
MKI49_RS03530 (678566) 678566..679996 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
MKI49_RS03535 (680015) 680015..681103 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-35)


Sequences


Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T236670 WP_002355568.1 NZ_CP092576:676358-676474 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

>T236670 NZ_LR699116:c53612-53208 [Aquicella lusitana]
ATGCGCTTAAGATATTTATTGGACACTAATATTTGTATTTATATAGCTAAGCAAAAGCCTGCAACAGTTATGAAGAAATT
TGAAGAGCTAGAAGTCGGACAAGTAGCAATGTCTGTTATTACCTATGGTGAACTTTTATATGGCGCTAATAAAAGTCAAT
CACCCGATGCTGCACATTCTAAACTAGTTGAACTAACCACGTTAATCCCTGCTTTAGAATTAAATAATGAAGTAGCTGAA
CATTATGGTGATATCAGAAGAAATTTAGAAAAATTTGGTAAACCAATTGGCAATAATGATCTTTGGATTGCATCGCATGC
ACGCGCATTAGATGTCATACTGGTTACAAATAATTTAAGGGAATTCGATAGAGTGCCAAAGTTAAGGATAGAGAATTGGG
TTTAA

Antitoxin


Download         Length: 136 bp

>AT236670 NZ_CP092576:c676592-676457 [Enterococcus faecalis]
TGAAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGG
TTTTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6


Antitoxin

Download structure file

References