Detailed information of TA system TA236667

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 676358..676590
• Replicon: chromosome
• Accession: NZ_CP092576
• Organism: Enterococcus faecalis strain VRE-WC031

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: C7CXQ5
• Locus tag: MKI49_RS03515
• Protein ID: WP_002355568.1
• Coordinates: 676358..676474 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	676385..676590 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI49_RS03505 (671796)	671796..674054	+	2259	WP_002363179.1	DNA helicase PcrA	-
MKI49_RS03510 (674180)	674180..676210	+	2031	WP_002368024.1	NAD-dependent DNA ligase LigA	-
MKI49_RS03515 (676358)	676358..676474	+	117	WP_002355568.1	putative holin-like toxin	Toxin
- (676385)	676385..676590	-	206	NuclAT_3	-	Antitoxin
- (676457)	676457..676592	-	136	NuclAT_5	-	-
- (676457)	676457..676612	-	156	NuclAT_12	-	-
MKI49_RS03520 (676792)	676792..677097	+	306	WP_002355569.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
MKI49_RS03525 (677097)	677097..678566	+	1470	WP_002368026.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
MKI49_RS03530 (678566)	678566..679996	+	1431	WP_002358703.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	-
MKI49_RS03535 (680015)	680015..681103	+	1089	WP_002355572.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4065.93 Da
• Isoelectric Point: 5.9482

>T236667 WP_002355568.1 NZ_CP092576:676358-676474 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Nucleotide

• Length: 117 bp

>T236667 NZ_LR699114:904507-904911 [Aquicella lusitana]
ATGCGCTTAAGATATTTATTGGACACTAATATTTGTATTTATATAGCTAAGCAAAAGCCTGCAACAGTTATGAAGAAATT
TGAAGAGCTAGAAGTCGGACAAGTAGCAATGTCTGTTATTACCTATGGTGAACTTTTATATGGCGCTAATAAAAGTCAAT
CACCCGATGCTGCACATTCTAAACTAGTTGAACTAACCACGTTAATCCCTGCTTTAGAATTAAATAATGAAGTAGCTGAA
CATTATGGTGATATCAGAAGAAATTTAGAAAAATTTGGTAAACCAATTGGCAATAATGATCTTTGGATTGCATCGCATGC
ACGCGCATTAGATGTCATACTGGTTACAAATAATTTAAGGGAATTCGATAGAGTGCCAAAGTTAAGGATAGAGAATTGGG
TTTAA

Antitoxin

Nucleotide

• Length: 206 bp

>AT236667 NZ_CP092576:c676590-676385 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGCGTTGCAAAACCAATCATCAGTCC

Structures

Toxin

• AlphaFold DB: A0A1B4XLM6

Antitoxin