Detailed information of TA system TA236661

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2994363..2994764
• Replicon: chromosome
• Accession: NZ_CP092574
• Organism: Enterococcus faecalis strain VSE-WC032

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: MKI56_RS14955
• Protein ID: WP_002392696.1
• Coordinates: 2994621..2994764 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2994363..2994508 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI56_RS14935	2989584..2990576	+	993	WP_002368503.1	biotin--[acetyl-CoA-carboxylase] ligase	-
MKI56_RS14940	2990840..2991478	-	639	WP_024041656.1	lytic polysaccharide monooxygenase	-
MKI56_RS14945	2992163..2993779	+	1617	WP_002368505.1	phosphatase PAP2/LCP family protein	-
MKI56_RS14950	2994048..2994191	+	144	WP_277813275.1	type I toxin-antitoxin system toxin PepG1	-
-	2994363..2994508	-	146	-	-	Antitoxin
MKI56_RS14955	2994621..2994764	+	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
MKI56_RS14960	2994954..2998013	-	3060	WP_002368508.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T236661 WP_002392696.1 NZ_CP092574:2994621-2994764 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T236661 NZ_LR699014:4056788-4057075 [Citrobacter werkmanii]
ATGAGTTATACGGTAAAGTTCAGGGAAGATGCGCTGAAAGAATGGCAAAAACTGGATAAAACCATTCAGCAGCAGTTTGC
CAAAAAACTCAAGAAATGCTGTGAAAATCCGCATGTCCCCTCCGAGAAGCTCGGGGGAATAAAAGATTGCTATAAAATCA
AACTACGCACTTCAGGGTTCCGTCTTGTTTATCAAGTTATTGACGAAACACTGGTCATCGCTGTCGTTGCCGTCGGTAAA
CGCGAGCGTAGTGAAGTTTATAATCTTGCCAGCGAAAGACTACGTTAA

Antitoxin

Nucleotide

• Length: 146 bp

>AT236661 NZ_CP092574:c2994508-2994363 [Enterococcus faecalis]
TGTGCTATAATAGCAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAACAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin