Detailed information of TA system TA236655

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2919573..2919835
• Replicon: chromosome
• Accession: NZ_CP092574
• Organism: Enterococcus faecalis strain VSE-WC032

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: MKI56_RS14615
• Protein ID: WP_002392696.1
• Coordinates: 2919692..2919835 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2919573..2919759 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI56_RS14600	2914940..2915653	-	714	WP_002354877.1	trehalose operon repressor	-
MKI56_RS15505	2915756..2915890	-	135	WP_002390296.1	hypothetical protein	-
MKI56_RS14605	2915914..2918658	+	2745	WP_002368465.1	glycosyl hydrolase family 65 protein	-
MKI56_RS14610	2918673..2919323	+	651	WP_002368467.1	beta-phosphoglucomutase	-
-	2919573..2919759	+	187	-	-	Antitoxin
MKI56_RS14615	2919692..2919835	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
MKI56_RS14620	2920067..2921038	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
MKI56_RS14625	2921213..2921650	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
MKI56_RS14630	2921783..2922337	-	555	WP_002354869.1	Maf family protein	-
MKI56_RS14635	2922362..2924494	-	2133	WP_002368469.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T236655 WP_002392696.1 NZ_CP092574:c2919835-2919692 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T236655 NZ_LR699014:c2076556-2076278 [Citrobacter werkmanii]
ATGATCATGAACTTCAGACACAAAGGATTGCGCGACTTGTTTCTTCAGGGGCGAACATCAGGCGTGACGGCGAAGCATGT
CCGGCGATTGCGGCACCGACTTGCCGTTATTGATGCAGCGAGCCATGTAACAGATATCAATATGCCTGGTTATAAACTGC
ATGCGTTAACTGGCGATCGCGACGGCGTTTGGTCGATTTCTGTTTCAGGCAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGATGCATATATACTGGATTACGAGGACTATCATTGA

Antitoxin

Nucleotide

• Length: 187 bp

>AT236655 NZ_CP092574:2919573-2919759 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAACCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin