Detailed information of TA system TA236652

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2851519..2851745
• Replicon: chromosome
• Accession: NZ_CP092574
• Organism: Enterococcus faecalis strain VSE-WC032

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MKI56_RS14295
• Protein ID: WP_021164442.1
• Coordinates: 2851644..2851745 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2851519..2851707 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI56_RS14270	2847139..2848092	-	954	WP_002368426.1	siderophore ABC transporter substrate-binding protein	-
MKI56_RS14275	2848131..2848886	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
MKI56_RS14280	2848883..2849848	-	966	WP_002368427.1	iron chelate uptake ABC transporter family permease subunit	-
MKI56_RS14285	2849845..2850792	-	948	WP_002368428.1	iron chelate uptake ABC transporter family permease subunit	-
MKI56_RS14290	2850977..2851429	+	453	WP_002368429.1	YueI family protein	-
-	2851519..2851707	+	189	-	-	Antitoxin
MKI56_RS14295	2851644..2851745	-	102	WP_021164442.1	putative holin-like toxin	Toxin
MKI56_RS14300	2851936..2854206	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
MKI56_RS14305	2854377..2854877	+	501	WP_024041671.1	cysteine hydrolase family protein	-
MKI56_RS14310	2855276..2856172	+	897	WP_002368434.1	YitT family protein	-
MKI56_RS14315	2856223..2856621	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3625.38 Da
• Isoelectric Point: 4.5869

>T236652 WP_021164442.1 NZ_CP092574:c2851745-2851644 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T236652 NZ_LR699014:575216-575539 [Citrobacter werkmanii]
ATGAAAATTCTACCGGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGCCACCCGTTGCAGTCTGGCAATTGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCAGTGATGAAACCGTTATAAAGGAACATTTCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGAATATTGATATCATGAGGGCCCGCCGCGATCTGGGTTTATTAAATCGTAA
TTAG

Antitoxin

Nucleotide

• Length: 189 bp

>AT236652 NZ_CP092574:2851519-2851707 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTTATACCAACGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAG
TTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATAC
CGAAAATCAGTAACGCAACAAGGGTTGCA

Structures

Antitoxin