Detailed information of TA system TA236643

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 676217..676449
• Replicon: chromosome
• Accession: NZ_CP092574
• Organism: Enterococcus faecalis strain VSE-WC032

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: C7CXQ5
• Locus tag: MKI56_RS03555
• Protein ID: WP_002355568.1
• Coordinates: 676217..676333 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	676244..676449 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI56_RS03545	671655..673913	+	2259	WP_002363179.1	DNA helicase PcrA	-
MKI56_RS03550	674039..676069	+	2031	WP_002368024.1	NAD-dependent DNA ligase LigA	-
MKI56_RS03555	676217..676333	+	117	WP_002355568.1	putative holin-like toxin	Toxin
-	676244..676449	-	206	-	-	Antitoxin
MKI56_RS03560	676651..676956	+	306	WP_002355569.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
MKI56_RS03565	676956..678425	+	1470	WP_002368026.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
MKI56_RS03570	678425..679855	+	1431	WP_002358703.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	-
MKI56_RS03575	679874..680962	+	1089	WP_002355572.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4065.93 Da
• Isoelectric Point: 5.9482

>T236643 WP_002355568.1 NZ_CP092574:676217-676333 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Nucleotide

• Length: 117 bp

>T236643 NZ_LR699009:c5377896-5377489 [Pluralibacter gergoviae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCGCGCAGTGGATCTCTTTGCTGCTTCACGGCGTAGTCGCCGC
GCTGGTGTTGCTGATGCCCTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGTAGCCAGCGGCGTATTAACGCCAGCCACGGTGAAATCAAGCTGCTCACCGATGCCCGCCTGCGCTGGCAGGATCAG
ACGTGGGACATTCTGGGAACGCCGTGGATGCTTGAAAGCGGCATGATGCTGCGGCTGAGGCGGCTGGATAATCGCAAAAA
GAGCCATCTGTGGATCGCGGCTGACAGCATGGACGCGGGAGAGTGGCGGGATCTGCGCCGCATGCTTCAGCAGCCGTCGG
CGCAGTAA

Antitoxin

Nucleotide

• Length: 206 bp

>AT236643 NZ_CP092574:c676449-676244 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGCGTTGCAAAACCAATCATCAGTCC

Structures

Toxin

• AlphaFold DB: A0A1B4XLM6

Antitoxin