Detailed information of TA system TA236636

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2509535..2509719
• Replicon: chromosome
• Accession: NZ_CP092567
• Organism: Staphylococcus aureus strain MRSA-WC000

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MKI50_RS12665
• Protein ID: WP_000482652.1
• Coordinates: 2509612..2509719 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2509535..2509595 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI50_RS12650 (MKI50_002507)	2504990..2505121	-	132	WP_223197975.1	hypothetical protein	-
MKI50_RS12655 (MKI50_002508)	2505388..2507121	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MKI50_RS12660 (MKI50_002509)	2507146..2508909	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2509535..2509595	+	61	-	-	Antitoxin
MKI50_RS12665 (MKI50_002510)	2509612..2509719	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MKI50_RS12670 (MKI50_002511)	2509853..2510239	-	387	WP_000779360.1	flippase GtxA	-
MKI50_RS12675 (MKI50_002512)	2510507..2511649	+	1143	WP_001176858.1	glycerate kinase	-
MKI50_RS12680 (MKI50_002513)	2511709..2512368	+	660	WP_000831298.1	membrane protein	-
MKI50_RS12685 (MKI50_002514)	2512550..2513761	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MKI50_RS12690 (MKI50_002515)	2513884..2514357	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T236636 WP_000482652.1 NZ_CP092567:c2509719-2509612 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T236636 NZ_LR699009:2552659-2553117 [Pluralibacter gergoviae]
GTGATCTTCTACCGGCTGACCAAGACGCGCTATCTGATGAGCGCCTGGTCGGGGCAGGGCGCCCGCGAAGCCGGAGGGCG
CTGGAACAGCGTCGGCACGGCGATGGTCTACCTGTCGCAGATGGCGTCGCTGACGATGCTGGAGACGCTGGTGCACCTCC
AGGCCCCGCAGCTGCTGGACGCCTTCACGCTGCTCAGCATTGAGATCCCGGACGAACAGATCCAGACCCTCGACAGGCAG
CGGCTGCCCGAAACCTGGTCCGGCGAAGAGGCGCCAGCCCAGCTGGCCCTGATCGGCGATGCGTGGATAGCCAGCGGCGT
ATCGCTGGCGCTGCGGGTGCCCAGCGCGCTCTCACCGGTAGAAGACAACTGTTTACTCAATCCTCAGCATCCTGCACTCT
TCGACATGATGGCCGGCGTGAAGAGAATTCCTTTCCGGTTTGATACGCGCCTTAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT236636 NZ_CP092567:2509535-2509595 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin