236635

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2484038..2484555 Replicon chromosome
Accession NZ_CP092567
Organism Staphylococcus aureus strain MRSA-WC000

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag MKI50_RS12530 Protein ID WP_000113265.1
Coordinates 2484038..2484304 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MKI50_RS12535 Protein ID WP_000584499.1
Coordinates 2484304..2484555 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI50_RS12500 (MKI50_002477) 2479466..2480002 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MKI50_RS12505 (MKI50_002478) 2480236..2481060 - 825 WP_000572038.1 formate/nitrite transporter family protein -
MKI50_RS12510 (MKI50_002479) 2481277..2481459 - 183 WP_000230292.1 hypothetical protein -
MKI50_RS12515 (MKI50_002480) 2481543..2482010 - 468 WP_000153347.1 SRPBCC domain-containing protein -
MKI50_RS12520 (MKI50_002481) 2482196..2483743 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MKI50_RS12525 (MKI50_002482) 2483932..2484003 - 72 Protein_2422 hypothetical protein -
MKI50_RS12530 (MKI50_002483) 2484038..2484304 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
MKI50_RS12535 (MKI50_002484) 2484304..2484555 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI50_RS12540 (MKI50_002485) 2484720..2484800 - 81 WP_223197974.1 hypothetical protein -
MKI50_RS12545 (MKI50_002486) 2484828..2485427 - 600 WP_000162810.1 DsbA family protein -
MKI50_RS12550 (MKI50_002487) 2485446..2485808 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MKI50_RS12555 (MKI50_002488) 2486063..2487313 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
MKI50_RS12560 (MKI50_002489) 2487410..2488141 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MKI50_RS12565 (MKI50_002490) 2488138..2488857 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T236635 WP_000113265.1 NZ_CP092567:c2484304-2484038 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T236635 NZ_LR699009:2265433-2266743 [Pluralibacter gergoviae]
ATGAAAAGCCTGTCGGTGTACATGAATGGCTATTTAGTCGGCACGCTGGGCATGGAGCCTGGCGGGGCAAATCTGTTTAC
CTATCACCAAAGCTGGCTGAATACGCCGCAGGCTCGCCCCGTATCGCTGTCCTTACCTTTACGCGAGCGGTCCTATGACG
GGGAGGTCGTCTTTAATTTTTTTGACAATCTGCTTCCCGACAGTCGCGAAATCCGCGAGCGTATTGCCGCCCGCTATCAC
GCTGACTCTCTGCGTCCGTTCGATCTTTTGTATGAGATCGGACGCGACTGCGTCGGCGCGGTGATCCTTCAGCCTCCTGA
TGAGGCTATCCAGGATATACAGCATATTTACAGTGAACGTCTGAATGAGGCTCAGCTGGACGCGATCCTAACAGGGTATC
TGAGCACCACTCGCTTTCGTCAGCAGGAAATACCGGATTTTCGAATCTCCATCGCAGGGGCCCAGGAGAAAACGGCACTC
CTTCACTATCAGGGCGACTGGCAGGTTCCGAAGGGAATTACGCCAACGACCCATATTTTTAAACTGCCTGTTGGTGAAAT
TCAGGGGCACAGTTTTACGCTTGACCTGCGCGATAGCGTTGAGAATGAGTGGCTAAGTATGCTGCTCGCCCGGCTATATG
GCTTCGAGGTCCCAGATTGCGAAATCGTGTTAACCCAAAATACCAAAGCGTTAGCCGTGCGCCGTTTTGATCGCCGTTTT
GTAGACGGTGAACGCTGGATTGCCCGTCTGCCGCAGGAGGATATGTGTCAGGCGCTTGGTGTCTCTTCGTCAAAAAAATA
TGAGAGCGACGGCGGGCCGGGAATTGAGGCGATAATGCGATTTTTACTGGGCTCTGATGCTGCGGAGCAGGATCGGGAAA
CGTTTATGCGCAGCCACATTCTTTTTTGGCTACTGGCGGCAAGCGACGGTCATGCGAAGAACTACTCTGTGGCTATTCTT
CCGGGAGGCGGCTATCGGCTGACGCCTCTTTACGACATCATGTCCTGCTACCCATTAATTGGCGGCCGCGGTCTGGCAAA
GCAGGATATTAAGATGGCGATGGCGCTCACGGCCACCGGACGCGGAAAGAAGTATGAATGGAGCACTATTTTTCCTCGCC
ACTTTATCGCTACAGCTAAAAAATGCGGCTTCAGTGAAGAGCGCATGGTGGAGCTGCTGCGGGAATTTGGTGAACAAACG
CCGCGAGTTTTAGCCGAGGCCGCGCGTTTGCTTCCCAAGGATTTTCCGCAGCACATCAGTGAAGCAATCTTTCTCGGCGT
CAGTAAAGCCGCCAAACGCCTGATGGTGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT236635 WP_000584499.1 NZ_CP092567:c2484555-2484304 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT236635 NZ_LR699009:2265184-2265432 [Pluralibacter gergoviae]
ATGAAAATTACCTCACCAGCGCAGCTGGCCATCTACCTCAAGGACCGCAGAAAGCAGCAGAAGCAGGCGCAGAGCACCGT
CGCCGAACGGGTTGGCCTGCGTCAGGACACGGTGTCTAAATTTGAGAACAGTCCCGATAAGAGCCAGATTGATACCCTGT
TTAAAATCCTCTCCTCGCTAAATATGGAGCTGCACCTTGAACCCAGAGAGGCGAAAAAGGCGGAGCAGGGCTGGAAAGAG
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References