Detailed information of TA system TA236629

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1879779..1879959
• Replicon: chromosome
• Accession: NZ_CP092567
• Organism: Staphylococcus aureus strain MRSA-WC000

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MKI50_RS09095
• Protein ID: WP_001801861.1
• Coordinates: 1879779..1879874 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1879902..1879959 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI50_RS09065 (MKI50_001794)	1874942..1875592	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
MKI50_RS09070 (MKI50_001795)	1875673..1876668	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
MKI50_RS09075 (MKI50_001796)	1876743..1877369	+	627	WP_000669024.1	hypothetical protein	-
MKI50_RS09080 (MKI50_001797)	1877410..1877751	+	342	WP_000627540.1	DUF3969 family protein	-
MKI50_RS09085 (MKI50_001798)	1877852..1878424	+	573	WP_000414216.1	hypothetical protein	-
MKI50_RS09090 (MKI50_001799)	1878622..1879634	-	1013	Protein_1788	IS3 family transposase	-
MKI50_RS09095 (MKI50_001800)	1879779..1879874	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1879902..1879959	-	58	-	-	Antitoxin
MKI50_RS09100 (MKI50_001801)	1879997..1880098	+	102	WP_001792025.1	hypothetical protein	-
MKI50_RS09105 (MKI50_001802)	1880076..1880237	-	162	Protein_1791	transposase	-
MKI50_RS09110 (MKI50_001803)	1880222..1880632	-	411	WP_001808705.1	IS21 family transposase	-
MKI50_RS09115 (MKI50_001804)	1881174..1882403	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
MKI50_RS09120 (MKI50_001805)	1882396..1883952	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MKI50_RS09125 (MKI50_001806)	1884116..1884250	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T236629 WP_001801861.1 NZ_CP092567:1879779-1879874 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T236629 NZ_LR699009:c812059-811688 [Pluralibacter gergoviae]
ATGGATGGCCCGGCCGTTTTCGATACTAATATCCTGATCGATCTCTTCAACAACCGCAGCGAGGCCGCCAATGCGATTGA
GCAACGCGGCCCGCACCGGGCGGTAAGTCTGGTGACCTGGATGGAGGTCATGGCGGGGGCGAAAAAGTACGGACAGGAGG
CCAGAACCGCTGGCGTGTTCAGCCTGTTCGAAGTCGTTGATATCAATAAAGAGATTGCCAGGCGCAGCGTCTCGCTGAGG
GCTACCTACGGCATGAAGCTCCCCGACGCCATTATACTGGCCACTGCGCAGGCGCGCGGCAGCGCGCTCATCACTCGCAA
TACCAAAGACTTCGCCGGTATTCCCGGCGTTATCACACCCTACCGGTTCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT236629 NZ_CP092567:c1879959-1879902 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin