Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1553421..1554000 | Replicon | chromosome |
| Accession | NZ_CP092567 | ||
| Organism | Staphylococcus aureus strain MRSA-WC000 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | MKI50_RS07475 | Protein ID | WP_001025401.1 |
| Coordinates | 1553755..1554000 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 1553421..1553786 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI50_RS07435 (MKI50_001468) | 1550164..1550721 | - | 558 | WP_000645048.1 | DUF2815 family protein | - |
| MKI50_RS07440 (MKI50_001469) | 1550747..1551913 | - | 1167 | WP_000762530.1 | DUF2800 domain-containing protein | - |
| MKI50_RS07445 (MKI50_001470) | 1551910..1552272 | - | 363 | WP_000985972.1 | hypothetical protein | - |
| MKI50_RS07450 (MKI50_001471) | 1552287..1552610 | - | 324 | WP_000174998.1 | hypothetical protein | - |
| MKI50_RS07455 (MKI50_001472) | 1552689..1552850 | - | 162 | WP_001285954.1 | DUF1270 domain-containing protein | - |
| MKI50_RS07460 (MKI50_001473) | 1552863..1553126 | - | 264 | WP_001124157.1 | helix-turn-helix domain-containing protein | - |
| MKI50_RS07465 (MKI50_001474) | 1553151..1553366 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| MKI50_RS07470 (MKI50_001475) | 1553421..1553786 | + | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| MKI50_RS07475 (MKI50_001476) | 1553755..1554000 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| MKI50_RS07480 (MKI50_001477) | 1554067..1554447 | + | 381 | WP_000773059.1 | DUF2513 domain-containing protein | - |
| MKI50_RS07485 (MKI50_001478) | 1554434..1554631 | - | 198 | WP_001148860.1 | hypothetical protein | - |
| MKI50_RS07490 (MKI50_001479) | 1554701..1554913 | + | 213 | WP_000362644.1 | hypothetical protein | - |
| MKI50_RS07495 (MKI50_001480) | 1554954..1555103 | - | 150 | WP_000771849.1 | hypothetical protein | - |
| MKI50_RS07500 (MKI50_001481) | 1555118..1555561 | - | 444 | WP_000435357.1 | hypothetical protein | - |
| MKI50_RS07505 (MKI50_001482) | 1555609..1555821 | - | 213 | WP_000213811.1 | helix-turn-helix transcriptional regulator | - |
| MKI50_RS07510 (MKI50_001483) | 1555973..1556704 | + | 732 | WP_000511090.1 | XRE family transcriptional regulator | - |
| MKI50_RS07515 (MKI50_001484) | 1556775..1556957 | + | 183 | WP_000705240.1 | hypothetical protein | - |
| MKI50_RS07520 (MKI50_001485) | 1556994..1557140 | + | 147 | WP_242417768.1 | hypothetical protein | - |
| MKI50_RS07525 (MKI50_001486) | 1557137..1557750 | - | 614 | Protein_1476 | ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1513616..1571833 | 58217 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T236626 WP_001025401.1 NZ_CP092567:c1554000-1553755 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T236626 NZ_LR699008:c4162404-4162093 [Hafnia alvei]
ATGGAGAAGCGAACGCCGCATTGTAGCTTGGAAAAGGTACGGAACTTGATTGGGAAGGGGATGATTAAAGCCACAAAAGT
CGCTTATTTGAATGCGAAGCGCCTCGATTTTAGCTGTGCAGATATGTATCGAGTCGTGAGTGAGTTATCTGCTAAAGACT
TTTATAAAAGTATGACAACGTATCAAAACCACAAAATTTGGCAGGATGTGTACCACTGCCATCTGGAAAAGGTATCTCTC
TATCTGAAACTAACGGTAGTGGATGAAGTGTTAATCGTGTCTTTTAAGGAGCTAGATGATGATATGTCCTGA
ATGGAGAAGCGAACGCCGCATTGTAGCTTGGAAAAGGTACGGAACTTGATTGGGAAGGGGATGATTAAAGCCACAAAAGT
CGCTTATTTGAATGCGAAGCGCCTCGATTTTAGCTGTGCAGATATGTATCGAGTCGTGAGTGAGTTATCTGCTAAAGACT
TTTATAAAAGTATGACAACGTATCAAAACCACAAAATTTGGCAGGATGTGTACCACTGCCATCTGGAAAAGGTATCTCTC
TATCTGAAACTAACGGTAGTGGATGAAGTGTTAATCGTGTCTTTTAAGGAGCTAGATGATGATATGTCCTGA
Antitoxin
Download Length: 366 bp
>AT236626 NZ_CP092567:1553421-1553786 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
