Detailed information of TA system TA236622

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2467741..2467925
• Replicon: chromosome
• Accession: NZ_CP092565
• Organism: Staphylococcus aureus strain MRSA-WC061

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MKI65_RS12350
• Protein ID: WP_000482652.1
• Coordinates: 2467818..2467925 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2467741..2467801 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI65_RS12335 (MKI65_002444)	2463196..2463327	-	132	WP_223197975.1	hypothetical protein	-
MKI65_RS12340 (MKI65_002445)	2463594..2465327	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MKI65_RS12345 (MKI65_002446)	2465352..2467115	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2467741..2467801	+	61	-	-	Antitoxin
MKI65_RS12350 (MKI65_002447)	2467818..2467925	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MKI65_RS12355 (MKI65_002448)	2468059..2468445	-	387	WP_000779360.1	flippase GtxA	-
MKI65_RS12360 (MKI65_002449)	2468713..2469855	+	1143	WP_001176858.1	glycerate kinase	-
MKI65_RS12365 (MKI65_002450)	2469915..2470574	+	660	WP_000831298.1	membrane protein	-
MKI65_RS12370 (MKI65_002451)	2470756..2471967	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MKI65_RS12375 (MKI65_002452)	2472090..2472563	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T236622 WP_000482652.1 NZ_CP092565:c2467925-2467818 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T236622 NZ_LR699008:2295235-2295756 [Hafnia alvei]
ATGCCTGACTTAACCATTGCGATTTTTTCGAGTGAGGCTGAATACGATTTCTCCGACTTTGACTGCGGCGAAGAATCCCT
GAATGTATTCCTTACCGATCATTTGGCCCGCCAGCATAATGCGCGAATTTTACGTGGCTATTTACTCATAACCCAAACGC
TAAAACCCAAAGTCGTTGGTTATTACACGCTATCTGGTAGCTGCTTCGAAAAGGAAACGCTGCCGTCAAATACCCAGAAA
CGCAAAGTGCCTTATGTCAACGTACCCAGTATCACTTTAGGGCGTCTCGCCATTCAAAAAGATCTCCATGGACAAGAATG
GGGAACGGCGCTGGTGACTCACGCGATGCAAGTGGTTTATCGAGCATCGCTTGCCGTGGGCGTTCACGGTATGTTTGTCG
ATGCACTCAATGAGAAAGCAAAGCAGTTCTACCTGAAGCTTGGATTTATCGCTCTCACGGGCAATAACGCAAACTCGCTT
TTCTACCCAACCAAATCCATCGAAAAGCTGTTCGAGGATTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT236622 NZ_CP092565:2467741-2467801 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin