Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2442246..2442763 | Replicon | chromosome |
| Accession | NZ_CP092565 | ||
| Organism | Staphylococcus aureus strain MRSA-WC061 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | MKI65_RS12215 | Protein ID | WP_000113265.1 |
| Coordinates | 2442246..2442512 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MKI65_RS12220 | Protein ID | WP_000584499.1 |
| Coordinates | 2442512..2442763 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI65_RS12185 (MKI65_002414) | 2437674..2438210 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| MKI65_RS12190 (MKI65_002415) | 2438444..2439268 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| MKI65_RS12195 (MKI65_002416) | 2439485..2439667 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| MKI65_RS12200 (MKI65_002417) | 2439751..2440218 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| MKI65_RS12205 (MKI65_002418) | 2440404..2441951 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MKI65_RS12210 (MKI65_002419) | 2442140..2442211 | - | 72 | Protein_2364 | hypothetical protein | - |
| MKI65_RS12215 (MKI65_002420) | 2442246..2442512 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| MKI65_RS12220 (MKI65_002421) | 2442512..2442763 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MKI65_RS12225 (MKI65_002422) | 2442928..2443008 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| MKI65_RS12230 (MKI65_002423) | 2443036..2443635 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| MKI65_RS12235 (MKI65_002424) | 2443654..2444016 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MKI65_RS12240 (MKI65_002425) | 2444271..2445521 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| MKI65_RS12245 (MKI65_002426) | 2445618..2446349 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| MKI65_RS12250 (MKI65_002427) | 2446346..2447065 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T236621 WP_000113265.1 NZ_CP092565:c2442512-2442246 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T236621 NZ_LR699008:738686-739099 [Hafnia alvei]
GTGGACCAATGGCGTTGTGATGTACGAGTGTCATGGCGAACGCAACTCTTGTTGTTAGTTACGCATGGCATTCTGATTTT
GTTGATTTTGCTAGCACCCTGGCCGGAAAACTATAGTTTTTATTGGTTGGTGTTGCTGACTTTAGTTGTGTTTGAATGTA
TCCGCAGCCAAAAGCAGATCGCTAAGATTCAGGGAGAGTTTAGCTTTCTAGCGGATAACCATATTCAATGGCAACAGAAC
GAATGGGAGTTATGTAAGACGCCTTGGATCAGTGATTTTGGCGCATTGCTACCCTTGAGAAGTGTGAAGCCGCAGGGAAC
GAAAAAGCGTTTATGGATTGCGGCAGACAGTTTGACGCCAGAGGCGTGGTGCCATTTGCGCCGCACTTTGATGCAAACCC
ACCAGAGTGATTAG
GTGGACCAATGGCGTTGTGATGTACGAGTGTCATGGCGAACGCAACTCTTGTTGTTAGTTACGCATGGCATTCTGATTTT
GTTGATTTTGCTAGCACCCTGGCCGGAAAACTATAGTTTTTATTGGTTGGTGTTGCTGACTTTAGTTGTGTTTGAATGTA
TCCGCAGCCAAAAGCAGATCGCTAAGATTCAGGGAGAGTTTAGCTTTCTAGCGGATAACCATATTCAATGGCAACAGAAC
GAATGGGAGTTATGTAAGACGCCTTGGATCAGTGATTTTGGCGCATTGCTACCCTTGAGAAGTGTGAAGCCGCAGGGAAC
GAAAAAGCGTTTATGGATTGCGGCAGACAGTTTGACGCCAGAGGCGTGGTGCCATTTGCGCCGCACTTTGATGCAAACCC
ACCAGAGTGATTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT236621 WP_000584499.1 NZ_CP092565:c2442763-2442512 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT236621 NZ_LR699008:738439-738705 [Hafnia alvei]
ATGGATATAGGAAATAAATCACGCATTCATTGGGCCTGTCGCCGCGGTATGCGTGAGCTGGATATCTCCATTATGCCGTT
TTTCGAACATGAGTATGATTCACTGAGCGATGCAGACAAACAGACATTTGTACGCTTACTTGAGTGCGACGATCCCGATC
TTTTTAATTGGCTCATGAACCACGGTTCACCCAAGGATCCTGAATTAGCGCATATGGTTAAACTTATTCAAACGCGAAAC
AAAGATCGTGGACCAATGGCGTTGTGA
ATGGATATAGGAAATAAATCACGCATTCATTGGGCCTGTCGCCGCGGTATGCGTGAGCTGGATATCTCCATTATGCCGTT
TTTCGAACATGAGTATGATTCACTGAGCGATGCAGACAAACAGACATTTGTACGCTTACTTGAGTGCGACGATCCCGATC
TTTTTAATTGGCTCATGAACCACGGTTCACCCAAGGATCCTGAATTAGCGCATATGGTTAAACTTATTCAAACGCGAAAC
AAAGATCGTGGACCAATGGCGTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|