Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | sprA1-sprA1AS/- |
| Location | 1837896..1838076 | Replicon | chromosome |
| Accession | NZ_CP092565 | ||
| Organism | Staphylococcus aureus strain MRSA-WC061 | ||
Toxin (Protein)
| Gene name | sprA1 | Uniprot ID | - |
| Locus tag | MKI65_RS08770 | Protein ID | WP_001801861.1 |
| Coordinates | 1837896..1837991 (+) | Length | 32 a.a. |
Antitoxin (RNA)
| Gene name | sprA1AS | ||
| Locus tag | - | ||
| Coordinates | 1838019..1838076 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI65_RS08740 (MKI65_001733) | 1833059..1833709 | + | 651 | WP_001795210.1 | excalibur calcium-binding domain-containing protein | - |
| MKI65_RS08745 (MKI65_001734) | 1833790..1834785 | + | 996 | WP_000070642.1 | DUF4352 domain-containing protein | - |
| MKI65_RS08750 (MKI65_001735) | 1834860..1835486 | + | 627 | WP_000669024.1 | hypothetical protein | - |
| MKI65_RS08755 (MKI65_001736) | 1835527..1835868 | + | 342 | WP_000627540.1 | DUF3969 family protein | - |
| MKI65_RS08760 (MKI65_001737) | 1835969..1836541 | + | 573 | WP_000414216.1 | hypothetical protein | - |
| MKI65_RS08765 (MKI65_001738) | 1836739..1837751 | - | 1013 | Protein_1726 | IS3 family transposase | - |
| MKI65_RS08770 (MKI65_001739) | 1837896..1837991 | + | 96 | WP_001801861.1 | type I toxin-antitoxin system Fst family toxin PepA1 | Toxin |
| - | 1838019..1838076 | - | 58 | - | - | Antitoxin |
| MKI65_RS08775 (MKI65_001740) | 1838114..1838215 | + | 102 | WP_001792025.1 | hypothetical protein | - |
| MKI65_RS08780 (MKI65_001741) | 1838193..1838354 | - | 162 | Protein_1729 | transposase | - |
| MKI65_RS08785 (MKI65_001742) | 1838339..1838749 | - | 411 | WP_001808705.1 | IS21 family transposase | - |
| MKI65_RS08790 (MKI65_001743) | 1839291..1840520 | - | 1230 | WP_000072627.1 | restriction endonuclease subunit S | - |
| MKI65_RS08795 (MKI65_001744) | 1840513..1842069 | - | 1557 | WP_000028669.1 | type I restriction-modification system subunit M | - |
| MKI65_RS08800 (MKI65_001745) | 1842233..1842367 | - | 135 | WP_001791797.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukD / hlgA / selk | 1832301..1864909 | 32608 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 32 a.a. Molecular weight: 3554.32 Da Isoelectric Point: 10.4449
>T236615 WP_001801861.1 NZ_CP092565:1837896-1837991 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
Download Length: 96 bp
>T236615 NZ_LR699006:c3738413-3738135 [Citrobacter freundii]
ATGATCATGAACTTCAGACACAAAGGATTGCGCGATTTGTTTCTTCATGGGCGAACATCAGGCGTTATGGCGAAGCATGT
CCGACGATTACGACACAGGCTTGCCGTTATTGATGCGGCAAGTAAGGTTACAGATATCAATATGCCCGGCTATAAGCTAC
ATCCTCTGGTGGGTGAGCGTGACGGCATATGGGCAATTTCTGTTTCAGGTAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGACGCGTACATACTGGACTACGAGGACTATCATTGA
ATGATCATGAACTTCAGACACAAAGGATTGCGCGATTTGTTTCTTCATGGGCGAACATCAGGCGTTATGGCGAAGCATGT
CCGACGATTACGACACAGGCTTGCCGTTATTGATGCGGCAAGTAAGGTTACAGATATCAATATGCCCGGCTATAAGCTAC
ATCCTCTGGTGGGTGAGCGTGACGGCATATGGGCAATTTCTGTTTCAGGTAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGACGCGTACATACTGGACTACGAGGACTATCATTGA
Antitoxin
Download Length: 58 bp
>AT236615 NZ_CP092565:c1838076-1838019 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
