Detailed information of TA system TA236611

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2468123..2468307
• Replicon: chromosome
• Accession: NZ_CP092563
• Organism: Staphylococcus aureus strain MRSA-WC090

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MKI59_RS12335
• Protein ID: WP_000482652.1
• Coordinates: 2468200..2468307 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2468123..2468183 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI59_RS12320 (MKI59_002446)	2463578..2463709	-	132	WP_223197975.1	hypothetical protein	-
MKI59_RS12325 (MKI59_002447)	2463976..2465709	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MKI59_RS12330 (MKI59_002448)	2465734..2467497	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2468123..2468183	+	61	-	-	Antitoxin
MKI59_RS12335 (MKI59_002449)	2468200..2468307	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MKI59_RS12340 (MKI59_002450)	2468441..2468827	-	387	WP_000779360.1	flippase GtxA	-
MKI59_RS12345 (MKI59_002451)	2469095..2470237	+	1143	WP_001176858.1	glycerate kinase	-
MKI59_RS12350 (MKI59_002452)	2470297..2470956	+	660	WP_000831298.1	membrane protein	-
MKI59_RS12355 (MKI59_002453)	2471138..2472349	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MKI59_RS12360 (MKI59_002454)	2472472..2472945	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T236611 WP_000482652.1 NZ_CP092563:c2468307-2468200 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T236611 NZ_LR699006:c1959791-1959411 [Citrobacter freundii]
ATGCAAACCTTATCCGCCATCCCGAAGCGGAAGGCACCGTCACGCCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAC
GTATCTGTTAAAAAGACATTACGGCCTTTCGCTTAGCGACACGCAATTTTCCGATGAGGAGATTATTACGCAATATATTG
ACGCCGGTATCTCACTGTCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTGCGGATTGATCGTCCCGGTTTC
TCCATTAAGCATCAGTCCCCTTTTATCGGGGTGATTGATATTCTCCGGGCCAGACGGGCAACGGGTTTGATGCAACGTAA
CGGGTATAAAAGGATCACTCTTCTCATCGCTGGAAATGCAGCTCAGGAGCAACATTCATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT236611 NZ_CP092563:2468123-2468183 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin