Detailed information of TA system TA236604

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1838277..1838457
• Replicon: chromosome
• Accession: NZ_CP092563
• Organism: Staphylococcus aureus strain MRSA-WC090

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MKI59_RS08765
• Protein ID: WP_001801861.1
• Coordinates: 1838277..1838372 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1838400..1838457 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI59_RS08735 (MKI59_001733)	1833440..1834090	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
MKI59_RS08740 (MKI59_001734)	1834171..1835166	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
MKI59_RS08745 (MKI59_001735)	1835241..1835867	+	627	WP_000669024.1	hypothetical protein	-
MKI59_RS08750 (MKI59_001736)	1835908..1836249	+	342	WP_000627540.1	DUF3969 family protein	-
MKI59_RS08755 (MKI59_001737)	1836350..1836922	+	573	WP_000414216.1	hypothetical protein	-
MKI59_RS08760 (MKI59_001738)	1837120..1838132	-	1013	Protein_1723	IS3 family transposase	-
MKI59_RS08765 (MKI59_001739)	1838277..1838372	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1838400..1838457	-	58	-	-	Antitoxin
MKI59_RS08770 (MKI59_001740)	1838495..1838596	+	102	WP_001792025.1	hypothetical protein	-
MKI59_RS08775 (MKI59_001741)	1838574..1838735	-	162	Protein_1726	transposase	-
MKI59_RS08780 (MKI59_001742)	1838720..1839130	-	411	WP_001808705.1	IS21 family transposase	-
MKI59_RS08785 (MKI59_001743)	1839672..1840901	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
MKI59_RS08790 (MKI59_001744)	1840894..1842450	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MKI59_RS08795 (MKI59_001745)	1842614..1842748	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1832682..1865290	32608

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T236604 WP_001801861.1 NZ_CP092563:1838277-1838372 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T236604 NZ_LR699003:c1144171-1143815 [Bifidobacterium breve]
ATGATGAAGACTGATCCGCACCAGTTCGAGATATGGTGGGTGCCGTTCACTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGTACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAGTCTTTTCCTCGACGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCACCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT236604 NZ_CP092563:c1838457-1838400 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin