Detailed information of TA system TA236600

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2467238..2467422
• Replicon: chromosome
• Accession: NZ_CP092561
• Organism: Staphylococcus aureus strain MRSA-WC101

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MKI54_RS12340
• Protein ID: WP_000482652.1
• Coordinates: 2467315..2467422 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2467238..2467298 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI54_RS12325 (MKI54_002443)	2462693..2462824	-	132	WP_223197975.1	hypothetical protein	-
MKI54_RS12330 (MKI54_002444)	2463091..2464824	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MKI54_RS12335 (MKI54_002445)	2464849..2466612	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2467238..2467298	+	61	-	-	Antitoxin
MKI54_RS12340 (MKI54_002446)	2467315..2467422	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MKI54_RS12345 (MKI54_002447)	2467556..2467942	-	387	WP_000779360.1	flippase GtxA	-
MKI54_RS12350 (MKI54_002448)	2468210..2469352	+	1143	WP_001176858.1	glycerate kinase	-
MKI54_RS12355 (MKI54_002449)	2469412..2470071	+	660	WP_000831298.1	membrane protein	-
MKI54_RS12360 (MKI54_002450)	2470253..2471464	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MKI54_RS12365 (MKI54_002451)	2471587..2472060	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T236600 WP_000482652.1 NZ_CP092561:c2467422-2467315 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T236600 NZ_LR698990:c302750-302451 [Bifidobacterium adolescentis]
ATGGGCCGGTTGACCGCCGACTTCGCGAAGGCCTTCAGCCGCGATCTGAAAAAGAACGCCAAACGGCGTAACTGGAACCT
GACCGAGCTTGAAAAAGTCATCGATCTGGTAGTGGAGAACACCCCGGAAACGCTGGAGGAGCTGCGCCGCCGCCACAACA
TGCACACCCTGTCCGGCAATTGGCGCGGGCGATACGAATGCCATGTCGCCAATGCCGGGGACTGGCTAGTGATCTGGTCA
TCGAACGATTCAGTCGCATTCTTCGAACGCACCGGCAGCCACGACGAATTATTCCGGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT236600 NZ_CP092561:2467238-2467298 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin