Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2441743..2442260 | Replicon | chromosome |
| Accession | NZ_CP092561 | ||
| Organism | Staphylococcus aureus strain MRSA-WC101 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | MKI54_RS12205 | Protein ID | WP_000113265.1 |
| Coordinates | 2441743..2442009 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MKI54_RS12210 | Protein ID | WP_000584499.1 |
| Coordinates | 2442009..2442260 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI54_RS12175 (MKI54_002413) | 2437171..2437707 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| MKI54_RS12180 (MKI54_002414) | 2437941..2438765 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| MKI54_RS12185 (MKI54_002415) | 2438982..2439164 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| MKI54_RS12190 (MKI54_002416) | 2439248..2439715 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| MKI54_RS12195 (MKI54_002417) | 2439901..2441448 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MKI54_RS12200 (MKI54_002418) | 2441637..2441708 | - | 72 | Protein_2357 | hypothetical protein | - |
| MKI54_RS12205 (MKI54_002419) | 2441743..2442009 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| MKI54_RS12210 (MKI54_002420) | 2442009..2442260 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MKI54_RS12215 (MKI54_002421) | 2442425..2442505 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| MKI54_RS12220 (MKI54_002422) | 2442533..2443132 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| MKI54_RS12225 (MKI54_002423) | 2443151..2443513 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MKI54_RS12230 (MKI54_002424) | 2443768..2445018 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| MKI54_RS12235 (MKI54_002425) | 2445115..2445846 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| MKI54_RS12240 (MKI54_002426) | 2445843..2446562 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T236599 WP_000113265.1 NZ_CP092561:c2442009-2441743 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T236599 NZ_LR698988:c2669312-2668929 [Lacticaseibacillus paracasei]
ATGGATGTGTCCGTAAAACGCGGCGATGTTTTTTTCGCCGATCTGTCTCCGGTTGTCGGCTCCGAACAAGGCGGCAACCG
GCCAGTACTTATTATTCAAAACAACGTTGGCAACCATTACAGTCCCACAGTGATTGTGGCAGCCATTACCTCCAAGATTC
AAAAACCCAAGATGCCGACGCATGTCGGGTTACGGGCCAAGCAAGATGGCGTTGAACGCAACTCAGTCATTTTACTTGAG
CAAATTCGCACGATTGACAAGCAACGGCTACAAGCCCGCGTGACAGCTCTGTCAAGCACCAAAATGGCAGCAGTCGACCG
CGCGTTGGCGATTTCAGTGGGCTTGGTTAGTTTGCCCAAGCCCAAAACATATAATAAGAATTAA
ATGGATGTGTCCGTAAAACGCGGCGATGTTTTTTTCGCCGATCTGTCTCCGGTTGTCGGCTCCGAACAAGGCGGCAACCG
GCCAGTACTTATTATTCAAAACAACGTTGGCAACCATTACAGTCCCACAGTGATTGTGGCAGCCATTACCTCCAAGATTC
AAAAACCCAAGATGCCGACGCATGTCGGGTTACGGGCCAAGCAAGATGGCGTTGAACGCAACTCAGTCATTTTACTTGAG
CAAATTCGCACGATTGACAAGCAACGGCTACAAGCCCGCGTGACAGCTCTGTCAAGCACCAAAATGGCAGCAGTCGACCG
CGCGTTGGCGATTTCAGTGGGCTTGGTTAGTTTGCCCAAGCCCAAAACATATAATAAGAATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT236599 WP_000584499.1 NZ_CP092561:c2442260-2442009 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT236599 NZ_LR698988:c2669580-2669332 [Lacticaseibacillus paracasei]
ATGAAAAAGCAAACGTCAGTAGCGGTAACGTTTGATGATGCCATTAAGGCGCGGTTGGATGCCTATTGTGAATTGAATGA
CATTGACGCTCAGGCTGTGATTACGGAGGCGGTGGCGACATTTTTGAAGTCACAGGCTCCCGAAATCAACCAATTGATTT
CTGGCTATGTAGCAATGGGCCAGATCAATACAGAGATCAGTCATGCTTTCTCTGCCTGCGAGAGCGAGGCATACGCCCAT
ATTCGATGA
ATGAAAAAGCAAACGTCAGTAGCGGTAACGTTTGATGATGCCATTAAGGCGCGGTTGGATGCCTATTGTGAATTGAATGA
CATTGACGCTCAGGCTGTGATTACGGAGGCGGTGGCGACATTTTTGAAGTCACAGGCTCCCGAAATCAACCAATTGATTT
CTGGCTATGTAGCAATGGGCCAGATCAATACAGAGATCAGTCATGCTTTCTCTGCCTGCGAGAGCGAGGCATACGCCCAT
ATTCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|