Detailed information of TA system TA236593

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1837385..1837565
• Replicon: chromosome
• Accession: NZ_CP092561
• Organism: Staphylococcus aureus strain MRSA-WC101

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MKI54_RS08770
• Protein ID: WP_001801861.1
• Coordinates: 1837385..1837480 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1837508..1837565 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI54_RS08740 (MKI54_001732)	1832548..1833198	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
MKI54_RS08745 (MKI54_001733)	1833279..1834274	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
MKI54_RS08750 (MKI54_001734)	1834349..1834975	+	627	WP_000669024.1	hypothetical protein	-
MKI54_RS08755 (MKI54_001735)	1835016..1835357	+	342	WP_000627540.1	DUF3969 family protein	-
MKI54_RS08760 (MKI54_001736)	1835458..1836030	+	573	WP_000414216.1	hypothetical protein	-
MKI54_RS08765 (MKI54_001737)	1836228..1837240	-	1013	Protein_1723	IS3 family transposase	-
MKI54_RS08770 (MKI54_001738)	1837385..1837480	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1837508..1837565	-	58	-	-	Antitoxin
MKI54_RS08775 (MKI54_001739)	1837603..1837704	+	102	WP_001792025.1	hypothetical protein	-
MKI54_RS08780 (MKI54_001740)	1837682..1837843	-	162	Protein_1726	transposase	-
MKI54_RS08785 (MKI54_001741)	1837828..1838238	-	411	WP_001808705.1	IS21 family transposase	-
MKI54_RS08790 (MKI54_001742)	1838780..1840009	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
MKI54_RS08795 (MKI54_001743)	1840002..1841558	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MKI54_RS08800 (MKI54_001744)	1841722..1841856	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1831790..1864402	32612

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T236593 WP_001801861.1 NZ_CP092561:1837385-1837480 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T236593 NZ_LR698987:1392979-1393332 [Leminorella richardii]
GTGTGGACAATTAAAACAACGGATAGGTTCGATAATTGGTTTACCTCACTCAGCGATACCGATCGCGTTAGTGTGCTCGC
TGCACTGATGATTCTGCGGGAAAGAGGGCCGGGGTTACCCAGACCTTATGCCGATACGCTCAGAGGCTCCAGCTATAGCA
ATATGAAAGAGCTGCGTATACAGAGTCGGGGCGATCCGATACGGGCATTTTTCGCTTTTGACCTTGAGCGCACTGGGATT
GTGCTGTGTGCTGGTAATAAAGTTGGTAATGAAAAGAGTTTTTACAATGAGATGCTCCCGATTGCAGACAGGGAGTTCAC
AAACTGGCTAAATACATTAAAAGAGAAGGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT236593 NZ_CP092561:c1837565-1837508 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin