Detailed information of TA system TA236588

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2464190..2464374
• Replicon: chromosome
• Accession: NZ_CP092558
• Organism: Staphylococcus aureus strain VMRSA-WC052

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MKI51_RS12340
• Protein ID: WP_000482652.1
• Coordinates: 2464267..2464374 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2464190..2464250 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI51_RS12325 (MKI51_002439)	2459645..2459776	-	132	WP_223197975.1	hypothetical protein	-
MKI51_RS12330 (MKI51_002440)	2460043..2461776	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MKI51_RS12335 (MKI51_002441)	2461801..2463564	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2464190..2464250	+	61	-	-	Antitoxin
MKI51_RS12340 (MKI51_002442)	2464267..2464374	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MKI51_RS12345 (MKI51_002443)	2464508..2464894	-	387	WP_000779360.1	flippase GtxA	-
MKI51_RS12350 (MKI51_002444)	2465162..2466304	+	1143	WP_001176858.1	glycerate kinase	-
MKI51_RS12355 (MKI51_002445)	2466364..2467023	+	660	WP_000831298.1	membrane protein	-
MKI51_RS12360 (MKI51_002446)	2467205..2468416	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MKI51_RS12365 (MKI51_002447)	2468539..2469012	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T236588 WP_000482652.1 NZ_CP092558:c2464374-2464267 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T236588 NZ_LR698983:c1361134-1360388 [Bacillus licheniformis]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTTATTGTTTTGGCGCTGGCTCTGTACGTAGCTGCCGTGTGGCGTTTTGA
AAAACAGCTCGCCGAAAAAACGGTCGCCATCAGAAAAACGTGGTACCTTCTTTATGTCATCGGCGCCGTGATATATTGGA
CGCACGATCCGCAGTCAATTTTCACAAACCCGCTTCATTACCTGATCGTTGCCGTTTTTTTCACGTTGACAGACGCTTTT
ATTTTCTTAAATGCCTACTTTAAAAAGCTCGGCAGCTCTGAACTCGCGACAGATACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACGTATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCGTATGCAGAAGGCATCGAAAAGCTCATCAAACGGTTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAAGATCATTTGCTTGAGCATATGGAAAACCGGTTCGATGTTCAAGAAAAGCTTGA
CCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGATTATCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGAAGGTGACGACTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT236588 NZ_CP092558:2464190-2464250 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin