Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2438695..2439212 | Replicon | chromosome |
| Accession | NZ_CP092558 | ||
| Organism | Staphylococcus aureus strain VMRSA-WC052 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | MKI51_RS12205 | Protein ID | WP_000113265.1 |
| Coordinates | 2438695..2438961 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MKI51_RS12210 | Protein ID | WP_000584499.1 |
| Coordinates | 2438961..2439212 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI51_RS12175 (MKI51_002409) | 2434123..2434659 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| MKI51_RS12180 (MKI51_002410) | 2434893..2435717 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| MKI51_RS12185 (MKI51_002411) | 2435934..2436116 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| MKI51_RS12190 (MKI51_002412) | 2436200..2436667 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| MKI51_RS12195 (MKI51_002413) | 2436853..2438400 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MKI51_RS12200 (MKI51_002414) | 2438589..2438660 | - | 72 | Protein_2362 | hypothetical protein | - |
| MKI51_RS12205 (MKI51_002415) | 2438695..2438961 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| MKI51_RS12210 (MKI51_002416) | 2438961..2439212 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MKI51_RS12215 (MKI51_002417) | 2439377..2439457 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| MKI51_RS12220 (MKI51_002418) | 2439485..2440084 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| MKI51_RS12225 (MKI51_002419) | 2440103..2440465 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MKI51_RS12230 (MKI51_002420) | 2440720..2441970 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| MKI51_RS12235 (MKI51_002421) | 2442067..2442798 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| MKI51_RS12240 (MKI51_002422) | 2442795..2443514 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T236587 WP_000113265.1 NZ_CP092558:c2438961-2438695 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T236587 NZ_LR698983:562820-563170 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT236587 WP_000584499.1 NZ_CP092558:c2439212-2438961 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT236587 NZ_LR698983:562534-562815 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|