Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | sprA1-sprA1AS/- |
| Location | 1834388..1834568 | Replicon | chromosome |
| Accession | NZ_CP092558 | ||
| Organism | Staphylococcus aureus strain VMRSA-WC052 | ||
Toxin (Protein)
| Gene name | sprA1 | Uniprot ID | - |
| Locus tag | MKI51_RS08760 | Protein ID | WP_001801861.1 |
| Coordinates | 1834388..1834483 (+) | Length | 32 a.a. |
Antitoxin (RNA)
| Gene name | sprA1AS | ||
| Locus tag | - | ||
| Coordinates | 1834511..1834568 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI51_RS08730 (MKI51_001728) | 1829551..1830201 | + | 651 | WP_001795210.1 | excalibur calcium-binding domain-containing protein | - |
| MKI51_RS08735 (MKI51_001729) | 1830282..1831277 | + | 996 | WP_000070642.1 | DUF4352 domain-containing protein | - |
| MKI51_RS08740 (MKI51_001730) | 1831352..1831978 | + | 627 | WP_000669024.1 | hypothetical protein | - |
| MKI51_RS08745 (MKI51_001731) | 1832019..1832360 | + | 342 | WP_000627540.1 | DUF3969 family protein | - |
| MKI51_RS08750 (MKI51_001732) | 1832461..1833033 | + | 573 | WP_000414216.1 | hypothetical protein | - |
| MKI51_RS08755 (MKI51_001733) | 1833231..1834243 | - | 1013 | Protein_1724 | IS3 family transposase | - |
| MKI51_RS08760 (MKI51_001734) | 1834388..1834483 | + | 96 | WP_001801861.1 | type I toxin-antitoxin system Fst family toxin PepA1 | Toxin |
| - | 1834511..1834568 | - | 58 | - | - | Antitoxin |
| MKI51_RS08765 (MKI51_001735) | 1834606..1834707 | + | 102 | WP_001792025.1 | hypothetical protein | - |
| MKI51_RS08770 (MKI51_001736) | 1834685..1834846 | - | 162 | Protein_1727 | transposase | - |
| MKI51_RS08775 (MKI51_001737) | 1834831..1835241 | - | 411 | WP_001808705.1 | IS21 family transposase | - |
| MKI51_RS08780 (MKI51_001738) | 1835783..1837012 | - | 1230 | WP_000072627.1 | restriction endonuclease subunit S | - |
| MKI51_RS08785 (MKI51_001739) | 1837005..1838561 | - | 1557 | WP_000028669.1 | type I restriction-modification system subunit M | - |
| MKI51_RS08790 (MKI51_001740) | 1838725..1838859 | - | 135 | WP_001791797.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukD / hlgA | 1810370..1861417 | 51047 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 32 a.a. Molecular weight: 3554.32 Da Isoelectric Point: 10.4449
>T236581 WP_001801861.1 NZ_CP092558:1834388-1834483 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
Download Length: 96 bp
>T236581 NZ_LR698969:207445-207639 [Murdochiella vaginalis]
ATGAATAAAGCAAATGTTCTCGCTCTTTGTCATAAGGTTGAGCAAAAAACAGGCCTTAGTTTCAATACGGTTCTGCTCTA
TTATTTTCTGGAAAGTATCTTAAAGCGTTTAACGGATGGGGAAAACAAGGATTCCTTTCGTCAAATGGTATCGCTTGATA
TCGCCATGGTGGATGTCATTACTCCTCTTTTTTGA
ATGAATAAAGCAAATGTTCTCGCTCTTTGTCATAAGGTTGAGCAAAAAACAGGCCTTAGTTTCAATACGGTTCTGCTCTA
TTATTTTCTGGAAAGTATCTTAAAGCGTTTAACGGATGGGGAAAACAAGGATTCCTTTCGTCAAATGGTATCGCTTGATA
TCGCCATGGTGGATGTCATTACTCCTCTTTTTTGA
Antitoxin
Download Length: 58 bp
>AT236581 NZ_CP092558:c1834568-1834511 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
