Detailed information of TA system TA236576

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2468699..2468883
• Replicon: chromosome
• Accession: NZ_CP092556
• Organism: Staphylococcus aureus strain VMRSA-WC062

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MKI64_RS12360
• Protein ID: WP_000482652.1
• Coordinates: 2468776..2468883 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2468699..2468759 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI64_RS12345 (MKI64_002445)	2464154..2464285	-	132	WP_223197975.1	hypothetical protein	-
MKI64_RS12350 (MKI64_002446)	2464552..2466285	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MKI64_RS12355 (MKI64_002447)	2466310..2468073	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2468699..2468759	+	61	-	-	Antitoxin
MKI64_RS12360 (MKI64_002448)	2468776..2468883	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MKI64_RS12365 (MKI64_002449)	2469017..2469403	-	387	WP_000779360.1	flippase GtxA	-
MKI64_RS12370 (MKI64_002450)	2469671..2470813	+	1143	WP_001176858.1	glycerate kinase	-
MKI64_RS12375 (MKI64_002451)	2470873..2471532	+	660	WP_000831298.1	membrane protein	-
MKI64_RS12380 (MKI64_002452)	2471714..2472925	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MKI64_RS12385 (MKI64_002453)	2473048..2473521	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T236576 WP_000482652.1 NZ_CP092556:c2468883-2468776 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T236576 NZ_LR698961:c284989-284588 [Helicobacter cinaedi]
ATGGCAAAAATAATGCTTGATACAAATATATGTATTTATATTATCAATAATAAACCGCAATATATTAAAGATAGATTTTT
ACAATACAGAATAGGCGATATTGCTATAAGCTCTATCAGTGTAGCTGAATTATACTTTGGTGTAGAAAAATCTCAATATA
AAGAAGCAAATACAAATGCTCTTAATACATTCCTAACACACCTTGAAGTAATAGATTTCGCACATAAAGAAGCGCTTACA
TATGCAAAAATTAGAGCAGATTTAGAATACAAAAAGTCTCTCATAGGTGCTATGGATATGCTTATTTCAGCGGTAGCTCT
TGCAAATGATTTAACACTTATTACAAATAACACAAAAGAATTTCAAAGAGTTAAGAATCTAAAAATAGAAAATTGGGTGT
GA

Antitoxin

Nucleotide

• Length: 61 bp

>AT236576 NZ_CP092556:2468699-2468759 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin