Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2443204..2443721 | Replicon | chromosome |
| Accession | NZ_CP092556 | ||
| Organism | Staphylococcus aureus strain VMRSA-WC062 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | MKI64_RS12225 | Protein ID | WP_000113265.1 |
| Coordinates | 2443204..2443470 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MKI64_RS12230 | Protein ID | WP_000584499.1 |
| Coordinates | 2443470..2443721 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI64_RS12195 (MKI64_002415) | 2438632..2439168 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| MKI64_RS12200 (MKI64_002416) | 2439402..2440226 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| MKI64_RS12205 (MKI64_002417) | 2440443..2440625 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| MKI64_RS12210 (MKI64_002418) | 2440709..2441176 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| MKI64_RS12215 (MKI64_002419) | 2441362..2442909 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MKI64_RS12220 (MKI64_002420) | 2443098..2443169 | - | 72 | Protein_2367 | hypothetical protein | - |
| MKI64_RS12225 (MKI64_002421) | 2443204..2443470 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| MKI64_RS12230 (MKI64_002422) | 2443470..2443721 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MKI64_RS12235 (MKI64_002423) | 2443886..2443966 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| MKI64_RS12240 (MKI64_002424) | 2443994..2444593 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| MKI64_RS12245 (MKI64_002425) | 2444612..2444974 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MKI64_RS12250 (MKI64_002426) | 2445229..2446479 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| MKI64_RS12255 (MKI64_002427) | 2446576..2447307 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| MKI64_RS12260 (MKI64_002428) | 2447304..2448023 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T236575 WP_000113265.1 NZ_CP092556:c2443470-2443204 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T236575 NZ_LR698956:c1117597-1117331 [Helicobacter pylori]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAACGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAAGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAGAGATGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAACGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAAGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAGAGATGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT236575 WP_000584499.1 NZ_CP092556:c2443721-2443470 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT236575 NZ_LR698956:c1117955-1117578 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGGTAAAAGAGGTTGTTGTTTG
GGGCACAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTCAACAAAGAAACTGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTAAAACTCAATCTTAA
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGGTAAAAGAGGTTGTTGTTTG
GGGCACAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTCAACAAAGAAACTGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTAAAACTCAATCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|