Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2467827..2468011 Replicon chromosome
Accession NZ_CP092554
Organism Staphylococcus aureus strain VMRSA-WC071

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag MKI61_RS12360 Protein ID WP_000482652.1
Coordinates 2467904..2468011 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2467827..2467887 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI61_RS12345 (MKI61_002447) 2463282..2463413 - 132 WP_223197975.1 hypothetical protein -
MKI61_RS12350 (MKI61_002448) 2463680..2465413 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
MKI61_RS12355 (MKI61_002449) 2465438..2467201 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 2467827..2467887 + 61 - - Antitoxin
MKI61_RS12360 (MKI61_002450) 2467904..2468011 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
MKI61_RS12365 (MKI61_002451) 2468145..2468531 - 387 WP_000779360.1 flippase GtxA -
MKI61_RS12370 (MKI61_002452) 2468799..2469941 + 1143 WP_001176858.1 glycerate kinase -
MKI61_RS12375 (MKI61_002453) 2470001..2470660 + 660 WP_000831298.1 membrane protein -
MKI61_RS12380 (MKI61_002454) 2470842..2472053 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
MKI61_RS12385 (MKI61_002455) 2472176..2472649 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T236564 WP_000482652.1 NZ_CP092554:c2468011-2467904 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T236564 NZ_LR698844:2721205-2721348 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 61 bp

>AT236564 NZ_CP092554:2467827-2467887 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References