Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 2442332..2442849 | Replicon | chromosome |
Accession | NZ_CP092554 | ||
Organism | Staphylococcus aureus strain VMRSA-WC071 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
Locus tag | MKI61_RS12225 | Protein ID | WP_000113265.1 |
Coordinates | 2442332..2442598 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | T1YB60 |
Locus tag | MKI61_RS12230 | Protein ID | WP_000584499.1 |
Coordinates | 2442598..2442849 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKI61_RS12195 (MKI61_002417) | 2437760..2438296 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
MKI61_RS12200 (MKI61_002418) | 2438530..2439354 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
MKI61_RS12205 (MKI61_002419) | 2439571..2439753 | - | 183 | WP_000230292.1 | hypothetical protein | - |
MKI61_RS12210 (MKI61_002420) | 2439837..2440304 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
MKI61_RS12215 (MKI61_002421) | 2440490..2442037 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
MKI61_RS12220 (MKI61_002422) | 2442226..2442297 | - | 72 | Protein_2365 | hypothetical protein | - |
MKI61_RS12225 (MKI61_002423) | 2442332..2442598 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
MKI61_RS12230 (MKI61_002424) | 2442598..2442849 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
MKI61_RS12235 (MKI61_002425) | 2443014..2443094 | - | 81 | WP_223197974.1 | hypothetical protein | - |
MKI61_RS12240 (MKI61_002426) | 2443122..2443721 | - | 600 | WP_000162810.1 | DsbA family protein | - |
MKI61_RS12245 (MKI61_002427) | 2443740..2444102 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
MKI61_RS12250 (MKI61_002428) | 2444357..2445607 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
MKI61_RS12255 (MKI61_002429) | 2445704..2446435 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
MKI61_RS12260 (MKI61_002430) | 2446432..2447151 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T236563 WP_000113265.1 NZ_CP092554:c2442598-2442332 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T236563 NZ_LR698844:2720834-2720974 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT236563 WP_000584499.1 NZ_CP092554:c2442849-2442598 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT236563 NZ_LR698844:c2721108-2720907 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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