Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-RelB |
Location | 1559944..1560456 | Replicon | chromosome |
Accession | NC_012466 | ||
Organism | Streptococcus pneumoniae JJA |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | C1CFW2 |
Locus tag | SPJ_RS08130 | Protein ID | WP_000924718.1 |
Coordinates | 1559944..1560198 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | K0ZY22 |
Locus tag | SPJ_RS08135 | Protein ID | WP_000388572.1 |
Coordinates | 1560202..1560456 (-) | Length | 85 a.a. |
Genomic Context
Location: 1557045..1557359 (315 bp)
Type: Others
Protein ID: WP_000979235.1
Type: Others
Protein ID: WP_000979235.1
Location: 1557384..1558010 (627 bp)
Type: Others
Protein ID: WP_000775037.1
Type: Others
Protein ID: WP_000775037.1
Location: 1558140..1559753 (1614 bp)
Type: Others
Protein ID: WP_000404940.1
Type: Others
Protein ID: WP_000404940.1
Location: 1559944..1560198 (255 bp)
Type: Toxin
Protein ID: WP_000924718.1
Type: Toxin
Protein ID: WP_000924718.1
Location: 1560202..1560456 (255 bp)
Type: Antitoxin
Protein ID: WP_000388572.1
Type: Antitoxin
Protein ID: WP_000388572.1
Location: 1560694..1561791 (1098 bp)
Type: Others
Protein ID: WP_000156351.1
Type: Others
Protein ID: WP_000156351.1
Location: 1561801..1562547 (747 bp)
Type: Others
Protein ID: WP_000605161.1
Type: Others
Protein ID: WP_000605161.1
Location: 1562650..1563003 (354 bp)
Type: Others
Protein ID: WP_001003001.1
Type: Others
Protein ID: WP_001003001.1
Location: 1563016..1563516 (501 bp)
Type: Others
Protein ID: WP_000781356.1
Type: Others
Protein ID: WP_000781356.1
Location: 1563517..1564110 (594 bp)
Type: Others
Protein ID: WP_000121674.1
Type: Others
Protein ID: WP_000121674.1
Location: 1564110..1564739 (630 bp)
Type: Others
Protein ID: WP_000151309.1
Type: Others
Protein ID: WP_000151309.1
Location: 1564791..1565102 (312 bp)
Type: Others
Protein ID: WP_000060169.1
Type: Others
Protein ID: WP_000060169.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SPJ_RS08115 | 1557045..1557359 | - | 315 | WP_000979235.1 | DNA-directed RNA polymerase subunit omega | - |
SPJ_RS08120 | 1557384..1558010 | - | 627 | WP_000775037.1 | guanylate kinase | - |
SPJ_RS08125 | 1558140..1559753 | - | 1614 | WP_000404940.1 | ribonuclease Y | - |
SPJ_RS08130 | 1559944..1560198 | - | 255 | WP_000924718.1 | Txe/YoeB family addiction module toxin | Toxin |
SPJ_RS08135 | 1560202..1560456 | - | 255 | WP_000388572.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
SPJ_RS08140 | 1560694..1561791 | - | 1098 | WP_000156351.1 | nucleotidyltransferase | - |
SPJ_RS08145 | 1561801..1562547 | - | 747 | WP_000605161.1 | class I SAM-dependent methyltransferase | - |
SPJ_RS08150 | 1562650..1563003 | - | 354 | WP_001003001.1 | ribosome silencing factor | - |
SPJ_RS08155 | 1563016..1563516 | - | 501 | WP_000781356.1 | cysteine hydrolase | - |
SPJ_RS08160 | 1563517..1564110 | - | 594 | WP_000121674.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK | - |
SPJ_RS08165 | 1564110..1564739 | - | 630 | WP_000151309.1 | nicotinate-nucleotide adenylyltransferase | - |
SPJ_RS08170 | 1564791..1565102 | - | 312 | WP_000060169.1 | ribosome assembly RNA-binding protein YhbY | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10131.55 Da Isoelectric Point: 7.9716
>T23656 WP_000924718.1 NC_012466:c1560198-1559944 [Streptococcus pneumoniae JJA]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIAKPEPLKYDYQGAWSRRIDAENRLIYMTDGDSMAFLSF
KDHY
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIAKPEPLKYDYQGAWSRRIDAENRLIYMTDGDSMAFLSF
KDHY
Download Length: 255 bp
>T23656 NC_012466:c1560198-1559944 [Streptococcus pneumoniae JJA]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGCAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGACGGATGGAGATAGCATGGCTTTCTTGTCCTTT
AAAGATCATTACTAA
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGCAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGACGGATGGAGATAGCATGGCTTTCTTGTCCTTT
AAAGATCATTACTAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9706.00 Da Isoelectric Point: 4.8430
>AT23656 WP_000388572.1 NC_012466:c1560456-1560202 [Streptococcus pneumoniae JJA]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE
Download Length: 255 bp
>AT23656 NC_012466:c1560456-1560202 [Streptococcus pneumoniae JJA]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTTCAT
GTGATTGAGGAGTGA
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTTCAT
GTGATTGAGGAGTGA