Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1559944..1560456 Replicon chromosome
Accession NC_012466
Organism Streptococcus pneumoniae JJA

Toxin (Protein)


Gene name yoeB Uniprot ID C1CFW2
Locus tag SPJ_RS08130 Protein ID WP_000924718.1
Coordinates 1559944..1560198 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag SPJ_RS08135 Protein ID WP_000388572.1
Coordinates 1560202..1560456 (-) Length 85 a.a.

Genomic Context


SPJ_RS08115SPJ_RS08120SPJ_RS08125SPJ_RS08130SPJ_RS08135SPJ_RS08140SPJ_RS08145SPJ_RS08150SPJ_RS08155SPJ_RS08160SPJ_RS08165SPJ_RS08170
Location: 1557045..1557359 (315 bp)
Type: Others
Protein ID: WP_000979235.1
Location: 1557384..1558010 (627 bp)
Type: Others
Protein ID: WP_000775037.1
Location: 1558140..1559753 (1614 bp)
Type: Others
Protein ID: WP_000404940.1
Location: 1559944..1560198 (255 bp)
Type: Toxin
Protein ID: WP_000924718.1
Location: 1560202..1560456 (255 bp)
Type: Antitoxin
Protein ID: WP_000388572.1
Location: 1560694..1561791 (1098 bp)
Type: Others
Protein ID: WP_000156351.1
Location: 1561801..1562547 (747 bp)
Type: Others
Protein ID: WP_000605161.1
Location: 1562650..1563003 (354 bp)
Type: Others
Protein ID: WP_001003001.1
Location: 1563016..1563516 (501 bp)
Type: Others
Protein ID: WP_000781356.1
Location: 1563517..1564110 (594 bp)
Type: Others
Protein ID: WP_000121674.1
Location: 1564110..1564739 (630 bp)
Type: Others
Protein ID: WP_000151309.1
Location: 1564791..1565102 (312 bp)
Type: Others
Protein ID: WP_000060169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SPJ_RS081151557045..1557359-315WP_000979235.1DNA-directed RNA polymerase subunit omega-
SPJ_RS081201557384..1558010-627WP_000775037.1guanylate kinase-
SPJ_RS081251558140..1559753-1614WP_000404940.1ribonuclease Y-
SPJ_RS081301559944..1560198-255WP_000924718.1Txe/YoeB family addiction module toxinToxin
SPJ_RS081351560202..1560456-255WP_000388572.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
SPJ_RS081401560694..1561791-1098WP_000156351.1nucleotidyltransferase-
SPJ_RS081451561801..1562547-747WP_000605161.1class I SAM-dependent methyltransferase-
SPJ_RS081501562650..1563003-354WP_001003001.1ribosome silencing factor-
SPJ_RS081551563016..1563516-501WP_000781356.1cysteine hydrolase-
SPJ_RS081601563517..1564110-594WP_000121674.1bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK-
SPJ_RS081651564110..1564739-630WP_000151309.1nicotinate-nucleotide adenylyltransferase-
SPJ_RS081701564791..1565102-312WP_000060169.1ribosome assembly RNA-binding protein YhbY-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-84)

Antitoxin

(1-75)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10131.55 Da        Isoelectric Point: 7.9716

>T23656 WP_000924718.1 NC_012466:c1560198-1559944 [Streptococcus pneumoniae JJA]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIAKPEPLKYDYQGAWSRRIDAENRLIYMTDGDSMAFLSF
KDHY

Download         Length: 255 bp

>T23656 NC_012466:c1560198-1559944 [Streptococcus pneumoniae JJA]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGCAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGACGGATGGAGATAGCATGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT23656 WP_000388572.1 NC_012466:c1560456-1560202 [Streptococcus pneumoniae JJA]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT23656 NC_012466:c1560456-1560202 [Streptococcus pneumoniae JJA]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTTCAT
GTGATTGAGGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBC1CFW2


Antitoxin

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Source
ID
Structure
AlphaFold DBK0ZY22

References