Detailed information of TA system TA236557

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1837892..1838072
• Replicon: chromosome
• Accession: NZ_CP092554
• Organism: Staphylococcus aureus strain VMRSA-WC071

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MKI61_RS08770
• Protein ID: WP_001801861.1
• Coordinates: 1837892..1837987 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1838015..1838072 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI61_RS08740 (MKI61_001733)	1833055..1833705	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
MKI61_RS08745 (MKI61_001734)	1833786..1834781	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
MKI61_RS08750 (MKI61_001735)	1834856..1835482	+	627	WP_000669024.1	hypothetical protein	-
MKI61_RS08755 (MKI61_001736)	1835523..1835864	+	342	WP_000627540.1	DUF3969 family protein	-
MKI61_RS08760 (MKI61_001737)	1835965..1836537	+	573	WP_000414216.1	hypothetical protein	-
MKI61_RS08765 (MKI61_001738)	1836735..1837747	-	1013	Protein_1726	IS3 family transposase	-
MKI61_RS08770 (MKI61_001739)	1837892..1837987	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1838015..1838072	-	58	-	-	Antitoxin
MKI61_RS08775 (MKI61_001740)	1838110..1838211	+	102	WP_001792025.1	hypothetical protein	-
MKI61_RS08780 (MKI61_001741)	1838189..1838350	-	162	Protein_1729	transposase	-
MKI61_RS08785 (MKI61_001742)	1838335..1838745	-	411	WP_001808705.1	IS21 family transposase	-
MKI61_RS08790 (MKI61_001743)	1839287..1840516	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
MKI61_RS08795 (MKI61_001744)	1840509..1842065	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MKI61_RS08800 (MKI61_001745)	1842229..1842363	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1832297..1864900	32603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T236557 WP_001801861.1 NZ_CP092554:1837892-1837987 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T236557 NZ_LR698844:2409213-2409557 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTTGAAGAATATAATGTGGAGTTGGTCTTTACTACATTACACAAAAAAGCTTGCTTCGA
ATCAGAACATGGTGTGATTTTTGTTAATCAAAATTTATCTACTGAAGAACAAGAAGAAGCAATTTATCATGAATTTAAGC
ACGTGAAAGATCATGCTGATTTGATGGCACTATACAACATCCCTATTTTTAGATCAAAAATGGAAGCAGAAGCTGAACAT
TATATGTTCGAATGTTTGATTGAAAAAAACGATGGTCAGTTTAATTATTCTAACGTAATTACACATTATAATTTAAAAAT
GGGGCAAGAAACTTATCTAAAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT236557 NZ_CP092554:c1838072-1838015 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin