Detailed information of TA system TA236552

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2464862..2465046
• Replicon: chromosome
• Accession: NZ_CP092552
• Organism: Staphylococcus aureus strain VMRSA-WC081

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MKI53_RS12305
• Protein ID: WP_000482652.1
• Coordinates: 2464939..2465046 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2464862..2464922 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI53_RS12290 (MKI53_002441)	2460317..2460448	-	132	WP_223197975.1	hypothetical protein	-
MKI53_RS12295 (MKI53_002442)	2460715..2462448	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MKI53_RS12300 (MKI53_002443)	2462473..2464236	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2464862..2464922	+	61	-	-	Antitoxin
MKI53_RS12305 (MKI53_002444)	2464939..2465046	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MKI53_RS12310 (MKI53_002445)	2465180..2465566	-	387	WP_000779360.1	flippase GtxA	-
MKI53_RS12315 (MKI53_002446)	2465834..2466976	+	1143	WP_001176858.1	glycerate kinase	-
MKI53_RS12320 (MKI53_002447)	2467036..2467695	+	660	WP_000831298.1	membrane protein	-
MKI53_RS12325 (MKI53_002448)	2467877..2469088	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MKI53_RS12330 (MKI53_002449)	2469211..2469684	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T236552 WP_000482652.1 NZ_CP092552:c2465046-2464939 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T236552 NZ_LR657304:3521841-3522419 [Pseudomonas aeruginosa PAK]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGTTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGTTCGGCGCGACGCCTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT236552 NZ_CP092552:2464862-2464922 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin