Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2439367..2439884 Replicon chromosome
Accession NZ_CP092552
Organism Staphylococcus aureus strain VMRSA-WC081

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag MKI53_RS12170 Protein ID WP_000113265.1
Coordinates 2439367..2439633 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MKI53_RS12175 Protein ID WP_000584499.1
Coordinates 2439633..2439884 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI53_RS12140 (MKI53_002411) 2434795..2435331 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MKI53_RS12145 (MKI53_002412) 2435565..2436389 - 825 WP_000572038.1 formate/nitrite transporter family protein -
MKI53_RS12150 (MKI53_002413) 2436606..2436788 - 183 WP_000230292.1 hypothetical protein -
MKI53_RS12155 (MKI53_002414) 2436872..2437339 - 468 WP_000153347.1 SRPBCC domain-containing protein -
MKI53_RS12160 (MKI53_002415) 2437525..2439072 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MKI53_RS12165 (MKI53_002416) 2439261..2439332 - 72 Protein_2351 hypothetical protein -
MKI53_RS12170 (MKI53_002417) 2439367..2439633 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
MKI53_RS12175 (MKI53_002418) 2439633..2439884 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI53_RS12180 (MKI53_002419) 2440049..2440129 - 81 WP_223197974.1 hypothetical protein -
MKI53_RS12185 (MKI53_002420) 2440157..2440756 - 600 WP_000162810.1 DsbA family protein -
MKI53_RS12190 (MKI53_002421) 2440775..2441137 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MKI53_RS12195 (MKI53_002422) 2441392..2442642 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
MKI53_RS12200 (MKI53_002423) 2442739..2443470 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MKI53_RS12205 (MKI53_002424) 2443467..2444186 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T236551 WP_000113265.1 NZ_CP092552:c2439633-2439367 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T236551 NZ_LR657304:1838979-1839566 [Pseudomonas aeruginosa PAK]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT236551 WP_000584499.1 NZ_CP092552:c2439884-2439633 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT236551 NZ_LR657304:1839633-1840487 [Pseudomonas aeruginosa PAK]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCATGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References