Detailed information of TA system TA236545

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1835025..1835205
• Replicon: chromosome
• Accession: NZ_CP092552
• Organism: Staphylococcus aureus strain VMRSA-WC081

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MKI53_RS08735
• Protein ID: WP_001801861.1
• Coordinates: 1835025..1835120 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1835148..1835205 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI53_RS08705 (MKI53_001728)	1830188..1830838	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
MKI53_RS08710 (MKI53_001729)	1830919..1831914	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
MKI53_RS08715 (MKI53_001730)	1831989..1832615	+	627	WP_000669024.1	hypothetical protein	-
MKI53_RS08720 (MKI53_001731)	1832656..1832997	+	342	WP_000627540.1	DUF3969 family protein	-
MKI53_RS08725 (MKI53_001732)	1833098..1833670	+	573	WP_000414216.1	hypothetical protein	-
MKI53_RS08730 (MKI53_001733)	1833868..1834880	-	1013	Protein_1717	IS3 family transposase	-
MKI53_RS08735 (MKI53_001734)	1835025..1835120	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1835148..1835205	-	58	-	-	Antitoxin
MKI53_RS08740 (MKI53_001735)	1835243..1835344	+	102	WP_001792025.1	hypothetical protein	-
MKI53_RS08745 (MKI53_001736)	1835322..1835483	-	162	Protein_1720	transposase	-
MKI53_RS08750 (MKI53_001737)	1835468..1835878	-	411	WP_001808705.1	IS21 family transposase	-
MKI53_RS08755 (MKI53_001738)	1836420..1837649	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
MKI53_RS08760 (MKI53_001739)	1837642..1839198	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MKI53_RS08765 (MKI53_001740)	1839362..1839496	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1811007..1871005	59998

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T236545 WP_001801861.1 NZ_CP092552:1835025-1835120 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T236545 NZ_LR655210:c1329643-1329287 [Bifidobacterium longum subsp. infantis]
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGATGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT236545 NZ_CP092552:c1835205-1835148 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin