Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2442627..2443144 Replicon chromosome
Accession NZ_CP092550
Organism Staphylococcus aureus strain VMRSA-WC082

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag MKI63_RS12230 Protein ID WP_000113265.1
Coordinates 2442627..2442893 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MKI63_RS12235 Protein ID WP_000584499.1
Coordinates 2442893..2443144 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI63_RS12200 (MKI63_002414) 2438055..2438591 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MKI63_RS12205 (MKI63_002415) 2438825..2439649 - 825 WP_000572038.1 formate/nitrite transporter family protein -
MKI63_RS12210 (MKI63_002416) 2439866..2440048 - 183 WP_000230292.1 hypothetical protein -
MKI63_RS12215 (MKI63_002417) 2440132..2440599 - 468 WP_000153347.1 SRPBCC domain-containing protein -
MKI63_RS12220 (MKI63_002418) 2440785..2442332 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MKI63_RS12225 (MKI63_002419) 2442521..2442592 - 72 Protein_2367 hypothetical protein -
MKI63_RS12230 (MKI63_002420) 2442627..2442893 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
MKI63_RS12235 (MKI63_002421) 2442893..2443144 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI63_RS12240 (MKI63_002422) 2443309..2443389 - 81 WP_223197974.1 hypothetical protein -
MKI63_RS12245 (MKI63_002423) 2443417..2444016 - 600 WP_000162810.1 DsbA family protein -
MKI63_RS12250 (MKI63_002424) 2444035..2444397 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MKI63_RS12255 (MKI63_002425) 2444652..2445902 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
MKI63_RS12260 (MKI63_002426) 2445999..2446730 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MKI63_RS12265 (MKI63_002427) 2446727..2447446 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T236539 WP_000113265.1 NZ_CP092550:c2442893-2442627 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T236539 NZ_LR595899:535107-535376 [Burkholderia pseudomallei]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT236539 WP_000584499.1 NZ_CP092550:c2443144-2442893 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT236539 NZ_LR595899:535360-535644 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAGGCAACGGGCGAAGGTTGGCAGACGCGCATG
AATGATGCGTTACGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References