Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | sprA1-sprA1AS/- |
| Location | 1838274..1838454 | Replicon | chromosome |
| Accession | NZ_CP092550 | ||
| Organism | Staphylococcus aureus strain VMRSA-WC082 | ||
Toxin (Protein)
| Gene name | sprA1 | Uniprot ID | - |
| Locus tag | MKI63_RS08785 | Protein ID | WP_001801861.1 |
| Coordinates | 1838274..1838369 (+) | Length | 32 a.a. |
Antitoxin (RNA)
| Gene name | sprA1AS | ||
| Locus tag | - | ||
| Coordinates | 1838397..1838454 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI63_RS08755 (MKI63_001733) | 1833437..1834087 | + | 651 | WP_001795210.1 | excalibur calcium-binding domain-containing protein | - |
| MKI63_RS08760 (MKI63_001734) | 1834168..1835163 | + | 996 | WP_000070642.1 | DUF4352 domain-containing protein | - |
| MKI63_RS08765 (MKI63_001735) | 1835238..1835864 | + | 627 | WP_000669024.1 | hypothetical protein | - |
| MKI63_RS08770 (MKI63_001736) | 1835905..1836246 | + | 342 | WP_000627540.1 | DUF3969 family protein | - |
| MKI63_RS08775 (MKI63_001737) | 1836347..1836919 | + | 573 | WP_000414216.1 | hypothetical protein | - |
| MKI63_RS08780 (MKI63_001738) | 1837117..1838129 | - | 1013 | Protein_1729 | IS3 family transposase | - |
| MKI63_RS08785 (MKI63_001739) | 1838274..1838369 | + | 96 | WP_001801861.1 | type I toxin-antitoxin system Fst family toxin PepA1 | Toxin |
| - | 1838397..1838454 | - | 58 | - | - | Antitoxin |
| MKI63_RS08790 (MKI63_001740) | 1838492..1838593 | + | 102 | WP_001792025.1 | hypothetical protein | - |
| MKI63_RS08795 (MKI63_001741) | 1838571..1838732 | - | 162 | Protein_1732 | transposase | - |
| MKI63_RS08800 (MKI63_001742) | 1838717..1839127 | - | 411 | WP_001808705.1 | IS21 family transposase | - |
| MKI63_RS08805 (MKI63_001743) | 1839669..1840898 | - | 1230 | WP_000072627.1 | restriction endonuclease subunit S | - |
| MKI63_RS08810 (MKI63_001744) | 1840891..1842447 | - | 1557 | WP_000028669.1 | type I restriction-modification system subunit M | - |
| MKI63_RS08815 (MKI63_001745) | 1842611..1842745 | - | 135 | WP_001791797.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukD / hlgA / selk | 1814256..1965913 | 151657 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 32 a.a. Molecular weight: 3554.32 Da Isoelectric Point: 10.4449
>T236533 WP_001801861.1 NZ_CP092550:1838274-1838369 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK
Download Length: 96 bp
>T236533 NZ_LR595895:536042-536311 [Burkholderia pseudomallei]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA
Antitoxin
Download Length: 58 bp
>AT236533 NZ_CP092550:c1838454-1838397 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
