Detailed information of TA system TA236533

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1838274..1838454
• Replicon: chromosome
• Accession: NZ_CP092550
• Organism: Staphylococcus aureus strain VMRSA-WC082

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MKI63_RS08785
• Protein ID: WP_001801861.1
• Coordinates: 1838274..1838369 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1838397..1838454 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI63_RS08755 (MKI63_001733)	1833437..1834087	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
MKI63_RS08760 (MKI63_001734)	1834168..1835163	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
MKI63_RS08765 (MKI63_001735)	1835238..1835864	+	627	WP_000669024.1	hypothetical protein	-
MKI63_RS08770 (MKI63_001736)	1835905..1836246	+	342	WP_000627540.1	DUF3969 family protein	-
MKI63_RS08775 (MKI63_001737)	1836347..1836919	+	573	WP_000414216.1	hypothetical protein	-
MKI63_RS08780 (MKI63_001738)	1837117..1838129	-	1013	Protein_1729	IS3 family transposase	-
MKI63_RS08785 (MKI63_001739)	1838274..1838369	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1838397..1838454	-	58	-	-	Antitoxin
MKI63_RS08790 (MKI63_001740)	1838492..1838593	+	102	WP_001792025.1	hypothetical protein	-
MKI63_RS08795 (MKI63_001741)	1838571..1838732	-	162	Protein_1732	transposase	-
MKI63_RS08800 (MKI63_001742)	1838717..1839127	-	411	WP_001808705.1	IS21 family transposase	-
MKI63_RS08805 (MKI63_001743)	1839669..1840898	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
MKI63_RS08810 (MKI63_001744)	1840891..1842447	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MKI63_RS08815 (MKI63_001745)	1842611..1842745	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1814256..1965913	151657

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T236533 WP_001801861.1 NZ_CP092550:1838274-1838369 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T236533 NZ_LR595895:536042-536311 [Burkholderia pseudomallei]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT236533 NZ_CP092550:c1838454-1838397 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin