Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2468038..2468222 Replicon chromosome
Accession NZ_CP092547
Organism Staphylococcus aureus strain VMRSA-WC083

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag MKI66_RS12370 Protein ID WP_000482652.1
Coordinates 2468115..2468222 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2468038..2468098 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI66_RS12355 (MKI66_002444) 2463493..2463624 - 132 WP_223197975.1 hypothetical protein -
MKI66_RS12360 (MKI66_002445) 2463891..2465624 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
MKI66_RS12365 (MKI66_002446) 2465649..2467412 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 2468038..2468098 + 61 - - Antitoxin
MKI66_RS12370 (MKI66_002447) 2468115..2468222 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
MKI66_RS12375 (MKI66_002448) 2468356..2468742 - 387 WP_000779360.1 flippase GtxA -
MKI66_RS12380 (MKI66_002449) 2469010..2470152 + 1143 WP_001176858.1 glycerate kinase -
MKI66_RS12385 (MKI66_002450) 2470212..2470871 + 660 WP_000831298.1 membrane protein -
MKI66_RS12390 (MKI66_002451) 2471053..2472264 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
MKI66_RS12395 (MKI66_002452) 2472387..2472860 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T236528 WP_000482652.1 NZ_CP092547:c2468222-2468115 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T236528 NZ_LR595855:4423321-4423539 [Raoultella terrigena]
ATGTCTGGTGAACCATTAACCAAAACAGACTATTTGATGCGCTTACGCCGTTGTCAGACAATTGATACGCTGGAACGCGT
AATTGAAAAAAATAAATACGAACTTCCGGACAACGAACTGGCTGTATTTTACTCAGCGGCCGATCACCGTCTTGCCGAAT
TGACCATGAATAAGCTCTACGACAAAATCCCGACGTCGGTATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 61 bp

>AT236528 NZ_CP092547:2468038-2468098 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References