Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2442543..2443060 Replicon chromosome
Accession NZ_CP092547
Organism Staphylococcus aureus strain VMRSA-WC083

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag MKI66_RS12235 Protein ID WP_000113265.1
Coordinates 2442543..2442809 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MKI66_RS12240 Protein ID WP_000584499.1
Coordinates 2442809..2443060 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI66_RS12205 (MKI66_002414) 2437971..2438507 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MKI66_RS12210 (MKI66_002415) 2438741..2439565 - 825 WP_000572038.1 formate/nitrite transporter family protein -
MKI66_RS12215 (MKI66_002416) 2439782..2439964 - 183 WP_000230292.1 hypothetical protein -
MKI66_RS12220 (MKI66_002417) 2440048..2440515 - 468 WP_000153347.1 SRPBCC domain-containing protein -
MKI66_RS12225 (MKI66_002418) 2440701..2442248 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MKI66_RS12230 (MKI66_002419) 2442437..2442508 - 72 Protein_2367 hypothetical protein -
MKI66_RS12235 (MKI66_002420) 2442543..2442809 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
MKI66_RS12240 (MKI66_002421) 2442809..2443060 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI66_RS12245 (MKI66_002422) 2443225..2443305 - 81 WP_223197974.1 hypothetical protein -
MKI66_RS12250 (MKI66_002423) 2443333..2443932 - 600 WP_000162810.1 DsbA family protein -
MKI66_RS12255 (MKI66_002424) 2443951..2444313 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MKI66_RS12260 (MKI66_002425) 2444568..2445818 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
MKI66_RS12265 (MKI66_002426) 2445915..2446646 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MKI66_RS12270 (MKI66_002427) 2446643..2447362 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T236527 WP_000113265.1 NZ_CP092547:c2442809-2442543 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T236527 NZ_LR595855:c2920372-2919053 [Raoultella terrigena]
ATGGCAACGCTCGTGACGTGGATGAACAATGAACGTGTCGGGGAGCTGGTCAAGCTGGCCAACGGCGCGCATCAGTTCCG
CTATGAACCGCGCTGGCTGCAAAACCCGCGCGCCCGCCCGCTCTCCCTGTCGCTGCCGCTGCAGTTCGGCAACATCACTT
CGGATGCGGTATTTAACTACTTCGACAACCTGCTGCCCGACAGCCCGCTGGTGCGTGACCGCATTGTTAAGCGCTATCAG
GCCCGCTCAAAGCAGCCCTTCGACCTGCTGGCCGAGGTGGGGCGCGACAGCGTCGGGGCGGTCACTCTTCTGCCCGAAGG
CGCCGCTCCGGCGACCGGCGCGCTGACCTGGGAAGCGCTCGACGACGCCCGGCTTGACGCGCTGCTGACGGCCTACCGCG
CGGATATACCGCTGGGTATGATTAACGGCCAGGAGGAGTTCAGAATATCGGTCGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGAAGATGGACGACCGCTGGTGCATACCGACGGCGACAACGCCGACGACGCATATTATTAAGCTGCCGATCGGCGAGAT
CAGGCAGCCGGACGCGGTGCTGGATCTCAGCGAAAGCGTCGATAACGAATATCTCTGTCTGGCCCTCGCGCGGGCGCTGG
GCTTTGCCGTGCCGGACGCGGAAATTATTACCACCCGCAGCATCCGGGCGCTGGCGGTGGCGCGTTTTGACCGCCGCTGG
GCGCAGGAAAACACGCGGCTGCTGCGCTTGCCACAGGAGGATCTGTGCCAGGCGTTCGGCATTCCTTCCTCGATGAAGTA
CGAATCCGACGGCGGGCCGGGGATCGCCAGCATCATGGCGTTTCTGCTTGGTTCCAGCGAGGCGCTGAAGGATCGCGCCG
ATTTTATGAAGTTCATCGTTTTTCAATGGCTGATCGGCGCCACCGACGGGCATGCGAAGAATTTTTCCATTTTCCTGCAG
CCCGGCGGCAGCTACCGCCTGACGCCGTTCTACGACATTATCTCGGCGTTTCCGCTGCTCGGCGGCGCGGGTTTGCATAT
CAGCGACCTTAAGCTGTCGATGAGCCTGAAAGCGTCGAAAGGGCGGAAAACGGAGATTCAGACCATCTACCCGCGTCATT
TCCTCGCCACGGCAAAAGAGGTGGGATTTGCGCAGCAGCAGATGCTGGAGATCCTGCGCTATTTTGCCGATAACCTGCCG
CGGGCGGTCGAGACGGTCAGCGCGTCGCTGCCGGAGGATTTTTCCCCGACGGTTTACCAGGCCATTATCTCGCACACCCT
CAGAAACCATGCCCGCCTGCAGAGCGGGCTAGCGGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT236527 WP_000584499.1 NZ_CP092547:c2443060-2442809 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT236527 NZ_LR595855:c2920641-2920372 [Raoultella terrigena]
ATAACGCCTCCGACGATCTACAGCCCGGCCCAGCTGGCAAACCATATCAAGCTGGTGCGGCAAAAAAACCAATGGACACA
AAGCGACCTGGCCCGCCGGATAGGCATTAAGCAGGCGACGATCTCGAACTTCGAAAACCATCCGGACAAAACCACCCTCA
CCACGCTGTTTAAGATTTTACAATCTCTTGAAATGACGATGGTGGTGTGCGAAAAGGGCGCCACGTCGGGTCCTGAGCAA
CAGGATAGCCAACGGGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References