Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 2442543..2443060 | Replicon | chromosome |
Accession | NZ_CP092547 | ||
Organism | Staphylococcus aureus strain VMRSA-WC083 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
Locus tag | MKI66_RS12235 | Protein ID | WP_000113265.1 |
Coordinates | 2442543..2442809 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | T1YB60 |
Locus tag | MKI66_RS12240 | Protein ID | WP_000584499.1 |
Coordinates | 2442809..2443060 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKI66_RS12205 (MKI66_002414) | 2437971..2438507 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
MKI66_RS12210 (MKI66_002415) | 2438741..2439565 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
MKI66_RS12215 (MKI66_002416) | 2439782..2439964 | - | 183 | WP_000230292.1 | hypothetical protein | - |
MKI66_RS12220 (MKI66_002417) | 2440048..2440515 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
MKI66_RS12225 (MKI66_002418) | 2440701..2442248 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
MKI66_RS12230 (MKI66_002419) | 2442437..2442508 | - | 72 | Protein_2367 | hypothetical protein | - |
MKI66_RS12235 (MKI66_002420) | 2442543..2442809 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
MKI66_RS12240 (MKI66_002421) | 2442809..2443060 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
MKI66_RS12245 (MKI66_002422) | 2443225..2443305 | - | 81 | WP_223197974.1 | hypothetical protein | - |
MKI66_RS12250 (MKI66_002423) | 2443333..2443932 | - | 600 | WP_000162810.1 | DsbA family protein | - |
MKI66_RS12255 (MKI66_002424) | 2443951..2444313 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
MKI66_RS12260 (MKI66_002425) | 2444568..2445818 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
MKI66_RS12265 (MKI66_002426) | 2445915..2446646 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
MKI66_RS12270 (MKI66_002427) | 2446643..2447362 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T236527 WP_000113265.1 NZ_CP092547:c2442809-2442543 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T236527 NZ_LR595855:c2920372-2919053 [Raoultella terrigena]
ATGGCAACGCTCGTGACGTGGATGAACAATGAACGTGTCGGGGAGCTGGTCAAGCTGGCCAACGGCGCGCATCAGTTCCG
CTATGAACCGCGCTGGCTGCAAAACCCGCGCGCCCGCCCGCTCTCCCTGTCGCTGCCGCTGCAGTTCGGCAACATCACTT
CGGATGCGGTATTTAACTACTTCGACAACCTGCTGCCCGACAGCCCGCTGGTGCGTGACCGCATTGTTAAGCGCTATCAG
GCCCGCTCAAAGCAGCCCTTCGACCTGCTGGCCGAGGTGGGGCGCGACAGCGTCGGGGCGGTCACTCTTCTGCCCGAAGG
CGCCGCTCCGGCGACCGGCGCGCTGACCTGGGAAGCGCTCGACGACGCCCGGCTTGACGCGCTGCTGACGGCCTACCGCG
CGGATATACCGCTGGGTATGATTAACGGCCAGGAGGAGTTCAGAATATCGGTCGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGAAGATGGACGACCGCTGGTGCATACCGACGGCGACAACGCCGACGACGCATATTATTAAGCTGCCGATCGGCGAGAT
CAGGCAGCCGGACGCGGTGCTGGATCTCAGCGAAAGCGTCGATAACGAATATCTCTGTCTGGCCCTCGCGCGGGCGCTGG
GCTTTGCCGTGCCGGACGCGGAAATTATTACCACCCGCAGCATCCGGGCGCTGGCGGTGGCGCGTTTTGACCGCCGCTGG
GCGCAGGAAAACACGCGGCTGCTGCGCTTGCCACAGGAGGATCTGTGCCAGGCGTTCGGCATTCCTTCCTCGATGAAGTA
CGAATCCGACGGCGGGCCGGGGATCGCCAGCATCATGGCGTTTCTGCTTGGTTCCAGCGAGGCGCTGAAGGATCGCGCCG
ATTTTATGAAGTTCATCGTTTTTCAATGGCTGATCGGCGCCACCGACGGGCATGCGAAGAATTTTTCCATTTTCCTGCAG
CCCGGCGGCAGCTACCGCCTGACGCCGTTCTACGACATTATCTCGGCGTTTCCGCTGCTCGGCGGCGCGGGTTTGCATAT
CAGCGACCTTAAGCTGTCGATGAGCCTGAAAGCGTCGAAAGGGCGGAAAACGGAGATTCAGACCATCTACCCGCGTCATT
TCCTCGCCACGGCAAAAGAGGTGGGATTTGCGCAGCAGCAGATGCTGGAGATCCTGCGCTATTTTGCCGATAACCTGCCG
CGGGCGGTCGAGACGGTCAGCGCGTCGCTGCCGGAGGATTTTTCCCCGACGGTTTACCAGGCCATTATCTCGCACACCCT
CAGAAACCATGCCCGCCTGCAGAGCGGGCTAGCGGGTTAG
ATGGCAACGCTCGTGACGTGGATGAACAATGAACGTGTCGGGGAGCTGGTCAAGCTGGCCAACGGCGCGCATCAGTTCCG
CTATGAACCGCGCTGGCTGCAAAACCCGCGCGCCCGCCCGCTCTCCCTGTCGCTGCCGCTGCAGTTCGGCAACATCACTT
CGGATGCGGTATTTAACTACTTCGACAACCTGCTGCCCGACAGCCCGCTGGTGCGTGACCGCATTGTTAAGCGCTATCAG
GCCCGCTCAAAGCAGCCCTTCGACCTGCTGGCCGAGGTGGGGCGCGACAGCGTCGGGGCGGTCACTCTTCTGCCCGAAGG
CGCCGCTCCGGCGACCGGCGCGCTGACCTGGGAAGCGCTCGACGACGCCCGGCTTGACGCGCTGCTGACGGCCTACCGCG
CGGATATACCGCTGGGTATGATTAACGGCCAGGAGGAGTTCAGAATATCGGTCGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGAAGATGGACGACCGCTGGTGCATACCGACGGCGACAACGCCGACGACGCATATTATTAAGCTGCCGATCGGCGAGAT
CAGGCAGCCGGACGCGGTGCTGGATCTCAGCGAAAGCGTCGATAACGAATATCTCTGTCTGGCCCTCGCGCGGGCGCTGG
GCTTTGCCGTGCCGGACGCGGAAATTATTACCACCCGCAGCATCCGGGCGCTGGCGGTGGCGCGTTTTGACCGCCGCTGG
GCGCAGGAAAACACGCGGCTGCTGCGCTTGCCACAGGAGGATCTGTGCCAGGCGTTCGGCATTCCTTCCTCGATGAAGTA
CGAATCCGACGGCGGGCCGGGGATCGCCAGCATCATGGCGTTTCTGCTTGGTTCCAGCGAGGCGCTGAAGGATCGCGCCG
ATTTTATGAAGTTCATCGTTTTTCAATGGCTGATCGGCGCCACCGACGGGCATGCGAAGAATTTTTCCATTTTCCTGCAG
CCCGGCGGCAGCTACCGCCTGACGCCGTTCTACGACATTATCTCGGCGTTTCCGCTGCTCGGCGGCGCGGGTTTGCATAT
CAGCGACCTTAAGCTGTCGATGAGCCTGAAAGCGTCGAAAGGGCGGAAAACGGAGATTCAGACCATCTACCCGCGTCATT
TCCTCGCCACGGCAAAAGAGGTGGGATTTGCGCAGCAGCAGATGCTGGAGATCCTGCGCTATTTTGCCGATAACCTGCCG
CGGGCGGTCGAGACGGTCAGCGCGTCGCTGCCGGAGGATTTTTCCCCGACGGTTTACCAGGCCATTATCTCGCACACCCT
CAGAAACCATGCCCGCCTGCAGAGCGGGCTAGCGGGTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT236527 WP_000584499.1 NZ_CP092547:c2443060-2442809 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT236527 NZ_LR595855:c2920641-2920372 [Raoultella terrigena]
ATAACGCCTCCGACGATCTACAGCCCGGCCCAGCTGGCAAACCATATCAAGCTGGTGCGGCAAAAAAACCAATGGACACA
AAGCGACCTGGCCCGCCGGATAGGCATTAAGCAGGCGACGATCTCGAACTTCGAAAACCATCCGGACAAAACCACCCTCA
CCACGCTGTTTAAGATTTTACAATCTCTTGAAATGACGATGGTGGTGTGCGAAAAGGGCGCCACGTCGGGTCCTGAGCAA
CAGGATAGCCAACGGGATCTGGAGTGGTAA
ATAACGCCTCCGACGATCTACAGCCCGGCCCAGCTGGCAAACCATATCAAGCTGGTGCGGCAAAAAAACCAATGGACACA
AAGCGACCTGGCCCGCCGGATAGGCATTAAGCAGGCGACGATCTCGAACTTCGAAAACCATCCGGACAAAACCACCCTCA
CCACGCTGTTTAAGATTTTACAATCTCTTGAAATGACGATGGTGGTGTGCGAAAAGGGCGCCACGTCGGGTCCTGAGCAA
CAGGATAGCCAACGGGATCTGGAGTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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