Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1838225..1838405 Replicon chromosome
Accession NZ_CP092547
Organism Staphylococcus aureus strain VMRSA-WC083

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag MKI66_RS08795 Protein ID WP_001801861.1
Coordinates 1838225..1838320 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1838348..1838405 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI66_RS08765 (MKI66_001733) 1833388..1834038 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
MKI66_RS08770 (MKI66_001734) 1834119..1835114 + 996 WP_000070642.1 DUF4352 domain-containing protein -
MKI66_RS08775 (MKI66_001735) 1835189..1835815 + 627 WP_000669024.1 hypothetical protein -
MKI66_RS08780 (MKI66_001736) 1835856..1836197 + 342 WP_000627540.1 DUF3969 family protein -
MKI66_RS08785 (MKI66_001737) 1836298..1836870 + 573 WP_000414216.1 hypothetical protein -
MKI66_RS08790 (MKI66_001738) 1837068..1838080 - 1013 Protein_1731 IS3 family transposase -
MKI66_RS08795 (MKI66_001739) 1838225..1838320 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1838348..1838405 - 58 - - Antitoxin
MKI66_RS08800 (MKI66_001740) 1838443..1838544 + 102 WP_001792025.1 hypothetical protein -
MKI66_RS08805 (MKI66_001741) 1838522..1838683 - 162 Protein_1734 transposase -
MKI66_RS08810 (MKI66_001742) 1838668..1839078 - 411 WP_001808705.1 IS21 family transposase -
MKI66_RS08815 (MKI66_001743) 1839620..1840849 - 1230 WP_000072627.1 restriction endonuclease subunit S -
MKI66_RS08820 (MKI66_001744) 1840842..1842398 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
MKI66_RS08825 (MKI66_001745) 1842562..1842696 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA / selk 1832630..1865238 32608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T236521 WP_001801861.1 NZ_CP092547:1838225-1838320 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T236521 NZ_LR595848:c1695661-1695482 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 58 bp

>AT236521 NZ_CP092547:c1838405-1838348 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References