Detailed information of TA system TA236516

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2468074..2468258
• Replicon: chromosome
• Accession: NZ_CP092544
• Organism: Staphylococcus aureus strain VMRSA-WC102

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MKI60_RS12345
• Protein ID: WP_000482652.1
• Coordinates: 2468151..2468258 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2468074..2468134 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI60_RS12330 (MKI60_002447)	2463529..2463660	-	132	WP_223197975.1	hypothetical protein	-
MKI60_RS12335 (MKI60_002448)	2463927..2465660	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MKI60_RS12340 (MKI60_002449)	2465685..2467448	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2468074..2468134	+	61	-	-	Antitoxin
MKI60_RS12345 (MKI60_002450)	2468151..2468258	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MKI60_RS12350 (MKI60_002451)	2468392..2468778	-	387	WP_000779360.1	flippase GtxA	-
MKI60_RS12355 (MKI60_002452)	2469046..2470188	+	1143	WP_001176858.1	glycerate kinase	-
MKI60_RS12360 (MKI60_002453)	2470248..2470907	+	660	WP_000831298.1	membrane protein	-
MKI60_RS12365 (MKI60_002454)	2471089..2472300	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MKI60_RS12370 (MKI60_002455)	2472423..2472896	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T236516 WP_000482652.1 NZ_CP092544:c2468258-2468151 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T236516 NZ_LR595692:47756-48061 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTCTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT236516 NZ_CP092544:2468074-2468134 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin