Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2441416..2441600 Replicon chromosome
Accession NZ_CP092542
Organism Staphylococcus aureus strain VRMSSA-WC113

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag MKI55_RS12200 Protein ID WP_000482652.1
Coordinates 2441493..2441600 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2441416..2441476 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI55_RS12185 (MKI55_002419) 2436871..2437002 - 132 WP_223197975.1 hypothetical protein -
MKI55_RS12190 (MKI55_002420) 2437269..2439002 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
MKI55_RS12195 (MKI55_002421) 2439027..2440790 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 2441416..2441476 + 61 - - Antitoxin
MKI55_RS12200 (MKI55_002422) 2441493..2441600 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
MKI55_RS12205 (MKI55_002423) 2441734..2442120 - 387 WP_000779360.1 flippase GtxA -
MKI55_RS12210 (MKI55_002424) 2442388..2443530 + 1143 WP_001176858.1 glycerate kinase -
MKI55_RS12215 (MKI55_002425) 2443590..2444249 + 660 WP_000831298.1 membrane protein -
MKI55_RS12220 (MKI55_002426) 2444431..2445642 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
MKI55_RS12225 (MKI55_002427) 2445765..2446238 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T236504 WP_000482652.1 NZ_CP092542:c2441600-2441493 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T236504 NZ_LR595691:c2120883-2120632 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 61 bp

>AT236504 NZ_CP092542:2441416-2441476 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References