Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2415921..2416438 | Replicon | chromosome |
| Accession | NZ_CP092542 | ||
| Organism | Staphylococcus aureus strain VRMSSA-WC113 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | MKI55_RS12065 | Protein ID | WP_000113265.1 |
| Coordinates | 2415921..2416187 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MKI55_RS12070 | Protein ID | WP_000584499.1 |
| Coordinates | 2416187..2416438 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI55_RS12035 (MKI55_002389) | 2411349..2411885 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| MKI55_RS12040 (MKI55_002390) | 2412119..2412943 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| MKI55_RS12045 (MKI55_002391) | 2413160..2413342 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| MKI55_RS12050 (MKI55_002392) | 2413426..2413893 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| MKI55_RS12055 (MKI55_002393) | 2414079..2415626 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MKI55_RS12060 (MKI55_002394) | 2415815..2415886 | - | 72 | Protein_2330 | hypothetical protein | - |
| MKI55_RS12065 (MKI55_002395) | 2415921..2416187 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| MKI55_RS12070 (MKI55_002396) | 2416187..2416438 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MKI55_RS12075 (MKI55_002397) | 2416603..2416683 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| MKI55_RS12080 (MKI55_002398) | 2416711..2417310 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| MKI55_RS12085 (MKI55_002399) | 2417329..2417691 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MKI55_RS12090 (MKI55_002400) | 2417946..2419196 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| MKI55_RS12095 (MKI55_002401) | 2419293..2420024 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| MKI55_RS12100 (MKI55_002402) | 2420021..2420740 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T236503 WP_000113265.1 NZ_CP092542:c2416187-2415921 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T236503 NZ_LR595691:c2120635-2120381 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT236503 WP_000584499.1 NZ_CP092542:c2416438-2416187 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT236503 NZ_LR595691:c2120883-2120632 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|