Detailed information of TA system TA236497

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1811564..1811744
• Replicon: chromosome
• Accession: NZ_CP092542
• Organism: Staphylococcus aureus strain VRMSSA-WC113

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MKI55_RS08630
• Protein ID: WP_001801861.1
• Coordinates: 1811564..1811659 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1811687..1811744 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI55_RS08600 (MKI55_001708)	1806727..1807377	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
MKI55_RS08605 (MKI55_001709)	1807458..1808453	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
MKI55_RS08610 (MKI55_001710)	1808528..1809154	+	627	WP_000669024.1	hypothetical protein	-
MKI55_RS08615 (MKI55_001711)	1809195..1809536	+	342	WP_000627540.1	DUF3969 family protein	-
MKI55_RS08620 (MKI55_001712)	1809637..1810209	+	573	WP_000414216.1	hypothetical protein	-
MKI55_RS08625 (MKI55_001713)	1810407..1811419	-	1013	Protein_1696	IS3 family transposase	-
MKI55_RS08630 (MKI55_001714)	1811564..1811659	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1811687..1811744	-	58	-	-	Antitoxin
MKI55_RS08635 (MKI55_001715)	1811782..1811883	+	102	WP_001792025.1	hypothetical protein	-
MKI55_RS08640 (MKI55_001716)	1811861..1812022	-	162	Protein_1699	transposase	-
MKI55_RS08645 (MKI55_001717)	1812007..1812417	-	411	WP_001808705.1	IS21 family transposase	-
MKI55_RS08650 (MKI55_001718)	1812959..1814188	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
MKI55_RS08655 (MKI55_001719)	1814181..1815737	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MKI55_RS08660 (MKI55_001720)	1815901..1816035	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1805969..1857982	52013

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T236497 WP_001801861.1 NZ_CP092542:1811564-1811659 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T236497 NZ_LR595691:c1139499-1138843 [Escherichia coli]
ATGGCTTATGATTACAGCGCCAGCCTCAACCCGCAAAAAGCTCTGATCTGGCGTATCGTCCATCGGGACAATATCCCGTG
GATTCTGGATAACGGGCTGCACTGCGGCAACAGTCTGGTGCAGGCGGAAAACTGGATCAATATCGGCAACCCGGAGCTGA
TCGGCAAGCGTGCCGGGCATCCGGTACCTGTCGGAACGGGCGGGACACTGCATGACTATGTGCCGTTTTATTTTACCCCC
TTCTCGCCAATGCTGATGAACATCCACAGCGGGCGCGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGCAACTTGCGAAACGTGGCAGCACACGACGTACCCTTCGTGTTTACCGACAGCCATGCTTACTATAACTGGACCAACT
ACTACACCAGTCTGGATAGTCTGGACCAGATCGACTGGCCCATTTTGCAGGCACGGGACTTTCGCCGCGATCCAGACGAT
CCGGCTAAATTTGAACGCTATCAGGCAGAGGCGCTAATCTGGCAACACTGCCCGATCTCTCTGCTGGATGGGATAATTTG
TTACAGCGAAGAGGTCAGGTTACAATTAGAACAATGGCTGTTTCAGCGTAATCTAACAATGTCCGTTCACACACGGGCTG
GATGGTACTTCTCATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT236497 NZ_CP092542:c1811744-1811687 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin