Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2468101..2468285 Replicon chromosome
Accession NZ_CP092540
Organism Staphylococcus aureus strain VMRSA-WC121

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag MKI67_RS12350 Protein ID WP_000482652.1
Coordinates 2468178..2468285 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2468101..2468161 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI67_RS12335 (MKI67_002448) 2463556..2463687 - 132 WP_223197975.1 hypothetical protein -
MKI67_RS12340 (MKI67_002449) 2463954..2465687 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
MKI67_RS12345 (MKI67_002450) 2465712..2467475 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 2468101..2468161 + 61 - - Antitoxin
MKI67_RS12350 (MKI67_002451) 2468178..2468285 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
MKI67_RS12355 (MKI67_002452) 2468419..2468805 - 387 WP_000779360.1 flippase GtxA -
MKI67_RS12360 (MKI67_002453) 2469073..2470215 + 1143 WP_001176858.1 glycerate kinase -
MKI67_RS12365 (MKI67_002454) 2470275..2470934 + 660 WP_000831298.1 membrane protein -
MKI67_RS12370 (MKI67_002455) 2471116..2472327 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
MKI67_RS12375 (MKI67_002456) 2472450..2472923 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-56)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T236492 WP_000482652.1 NZ_CP092540:c2468285-2468178 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T236492 NZ_LR594691:c326878-326702 [Variovorax sp. WDL1]
ATGAAAACTTCAGAATTCAAGCGCTTCCTTGCCTCGAAGGGGGCCCGATTCGTTGAGGGCTCAAAGCACACGAAGGTCTA
TCTCGGCACCAAGCAAACGATGCTGCCGAGGCATTCGAAGGAAATTGGCGAGGGCCTGCGCAAGAGCATCCTGCGCCAGC
TCGGCATCAAAGATTGA

Antitoxin


Download         Length: 61 bp

>AT236492 NZ_CP092540:2468101-2468161 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References