Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2467680..2467864 Replicon chromosome
Accession NZ_CP092538
Organism Staphylococcus aureus strain VMRSA-WC123

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag MKI57_RS12355 Protein ID WP_000482652.1
Coordinates 2467757..2467864 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2467680..2467740 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI57_RS12340 (MKI57_002446) 2463135..2463266 - 132 WP_223197975.1 hypothetical protein -
MKI57_RS12345 (MKI57_002447) 2463533..2465266 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
MKI57_RS12350 (MKI57_002448) 2465291..2467054 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 2467680..2467740 + 61 - - Antitoxin
MKI57_RS12355 (MKI57_002449) 2467757..2467864 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
MKI57_RS12360 (MKI57_002450) 2467998..2468384 - 387 WP_000779360.1 flippase GtxA -
MKI57_RS12365 (MKI57_002451) 2468652..2469794 + 1143 WP_001176858.1 glycerate kinase -
MKI57_RS12370 (MKI57_002452) 2469854..2470513 + 660 WP_000831298.1 membrane protein -
MKI57_RS12375 (MKI57_002453) 2470695..2471906 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
MKI57_RS12380 (MKI57_002454) 2472029..2472502 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T236480 WP_000482652.1 NZ_CP092538:c2467864-2467757 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T236480 NZ_CP092538:c2467864-2467757 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT236480 NZ_CP092538:2467680-2467740 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References