236479

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2442185..2442702 Replicon chromosome
Accession NZ_CP092538
Organism Staphylococcus aureus strain VMRSA-WC123

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag MKI57_RS12220 Protein ID WP_000113265.1
Coordinates 2442185..2442451 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MKI57_RS12225 Protein ID WP_000584499.1
Coordinates 2442451..2442702 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI57_RS12190 (MKI57_002416) 2437613..2438149 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MKI57_RS12195 (MKI57_002417) 2438383..2439207 - 825 WP_000572038.1 formate/nitrite transporter family protein -
MKI57_RS12200 (MKI57_002418) 2439424..2439606 - 183 WP_000230292.1 hypothetical protein -
MKI57_RS12205 (MKI57_002419) 2439690..2440157 - 468 WP_000153347.1 SRPBCC domain-containing protein -
MKI57_RS12210 (MKI57_002420) 2440343..2441890 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MKI57_RS12215 (MKI57_002421) 2442079..2442150 - 72 Protein_2365 hypothetical protein -
MKI57_RS12220 (MKI57_002422) 2442185..2442451 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
MKI57_RS12225 (MKI57_002423) 2442451..2442702 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI57_RS12230 (MKI57_002424) 2442867..2442947 - 81 WP_223197974.1 hypothetical protein -
MKI57_RS12235 (MKI57_002425) 2442975..2443574 - 600 WP_000162810.1 DsbA family protein -
MKI57_RS12240 (MKI57_002426) 2443593..2443955 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MKI57_RS12245 (MKI57_002427) 2444210..2445460 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
MKI57_RS12250 (MKI57_002428) 2445557..2446288 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MKI57_RS12255 (MKI57_002429) 2446285..2447004 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T236479 WP_000113265.1 NZ_CP092538:c2442451-2442185 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T236479 NZ_LR594675:c1984904-1984533 [Variovorax sp. PBS-H4]
ATGATCCTCGTTGACACGTCGGTATGGATCGACCACCTGGCCCGGGGCGATTCAAGATTGCAATCGCTGCTGGAGGAAGG
TGAAGTCCTCATGCATCCATACATCGTCGCGGAGATTGCTTTGGGCAGCCTGACTCGGCGAAAAGAGACCGTCGGCGCGT
TGCAGGCCTTGCCCGAGATTCCGGCGGCGCGCCATGACGAGGTCATGGCGTTCCTTGGCAACGAGCGCTTGTTCGGCCTC
GGGATCGGCTATGTCGATCTTCACTTGCTTGCCGCGACTCGCCTCGCCGTTGGCACGAAGCTATGGACACGCGATCGACG
CCTTCTTCAAGCGGCACTGAAATTTAACCTGGCTGCGTTCGCCGCACATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT236479 WP_000584499.1 NZ_CP092538:c2442702-2442451 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT236479 NZ_LR594675:c1985100-1984891 [Variovorax sp. PBS-H4]
ATGCGCACCACCGTCACCTTGGACGACGAGCTGCTCTCTCAAGCTCGGACATTCACGGGCATCCAGGAGAACTCCGCGCT
GATCCAACAGGCGCTCAAAACCCTTGTCCAGAGGGAAGCCGCCCGTCGGCTGGCGCGCTTGGGAGGCAGCGCGCCGGGCC
TCCAGGCTGCGCCGAGACGCCGGGGAAAAGGCGCGAATGATCCTCGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References