Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 726264..726957 Replicon chromosome
Accession NZ_CP092534
Organism Escherichia coli strain DS566

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MKD44_RS03520 Protein ID WP_000415584.1
Coordinates 726264..726560 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MKD44_RS03525 Protein ID WP_000650107.1
Coordinates 726562..726957 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD44_RS03485 (721352) 721352..721666 - 315 WP_000958598.1 putative quinol monooxygenase -
MKD44_RS03490 (721697) 721697..722278 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MKD44_RS03495 (722597) 722597..722929 + 333 WP_000917685.1 DUF2645 family protein -
MKD44_RS03500 (722975) 722975..724324 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MKD44_RS03505 (724321) 724321..724980 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
MKD44_RS03510 (725132) 725132..725524 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MKD44_RS03515 (725577) 725577..726059 + 483 WP_000183505.1 GyrI-like domain-containing protein -
MKD44_RS03520 (726264) 726264..726560 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MKD44_RS03525 (726562) 726562..726957 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MKD44_RS03530 (727090) 727090..728697 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MKD44_RS03535 (728835) 728835..731093 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T236426 WP_000415584.1 NZ_CP092534:726264-726560 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T236426 NZ_LR594038:897074-897397 [Klebsiella grimontii]
ATGAAATTTCTACCTACAACAAATATGCGGGCGGCGAAGCCATGCCTGTCGCCCGTGACTATCTGGCAAATGCTACTTAG
TCGTCTGCTGGAACAGCATTATGGCCTGACACTAAACGATACACCTTTCTGTGATGAAACCGTCATACAGGAACATATCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGATTATTGATATCATGAGGGCCCGTCGCGATCTGGGTTTAATGAATCGTAA
TTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT236426 WP_000650107.1 NZ_CP092534:726562-726957 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT236426 NZ_LR594038:896697-897053 [Klebsiella grimontii]
ATGAACTATCACTCAGAATCCGGTGCCATACCGGAGAATCCCCCCTGCCAGCATTGGGGGCTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGGCTGGTGCAAGAAGGAGACCGCCTGCATTTTCTTGCTGATCGGGCCGGATTTAACGGTGCTTTCT
GCGACGATGACGCGCTATACCTGGATCAGGCCTTTCCGTTGATTCTCAAACAACTGGAGCTGACACTCACCAGCGGAGAA
CTCTCCCCCCGCCATCAGCACTGTGTCACCCTCTATCACAACGGACTCACCTGCGAAGCCGATACGCTTGGTAGTTGTGG
CTACGTATACATCGCCATTTATCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References