Detailed information of TA system TA236415

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4030835..4031093
• Replicon: chromosome
• Accession: NZ_CP092533
• Organism: Escherichia coli strain DS566-1

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: MKD47_RS19590
• Protein ID: WP_000809168.1
• Coordinates: 4030941..4031093 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4030835..4030892 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKD47_RS19575	4026664..4027923	-	1260	WP_000494929.1	hypothetical protein	-
MKD47_RS19580	4028052..4029545	-	1494	WP_001774152.1	sulfatase-like hydrolase/transferase	-
MKD47_RS19585	4029565..4030326	-	762	WP_001274832.1	outer membrane protein OmpK	-
-	4030835..4030892	-	58	-	-	Antitoxin
MKD47_RS19590	4030941..4031093	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
MKD47_RS19595	4031198..4032328	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
MKD47_RS19600	4032417..4034333	-	1917	WP_000516135.1	molecular chaperone DnaK	-
MKD47_RS19605	4034705..4035109	+	405	WP_000843687.1	DUF2541 family protein	-
MKD47_RS19610	4035135..4035848	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T236415 WP_000809168.1 NZ_CP092533:4030941-4031093 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T236415 NZ_LR593886:3128515-3129033 [Gemmata massiliana]
ATGACCCGGGGGCACGTGTCCCCGCCCGCGCTCCTGACGGACGGGCACGACCTGGCTCCGTTCGATTGCGGCGTGCCGTC
CCTCAACGACTGGCTGAGGCGACGGGCGCTCAAGAACAACCGGTCGGGCGCCTCGCGCACGTACGTCCTGTGCAACGGGG
CCGTGGTCGTGGGCTACTACTGCCTGGCCACGGGAGCCGTCTACCACGACGACGCGCCACACGCGCTGCGGCGGAACATG
CCCGATCCCATTCCCGTCCTGGTGCTCGGGCGCCTGGCCGTTGATCGCCGGTGCCAGAATCAAAAAATCGGACGCGCGAT
GTTGCGTGACGCCGCGCTACGGGCCCAGGAGGTCGCCGAGAGCGTCGGGGTGACGGCCATTGTGGTCCATGCCATTTCTG
AGGAGGCCCGGCGCTTCTACGTGTCGTGTGGCTTCGTGGAATCACCGCTGCAACCCATGACACTCTGCCTGTTGATGGCC
ACGCTGCAGAACACGGGCGCCCGGCTCCTGATTAGTTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT236415 NZ_CP092533:c4030892-4030835 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin