Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 726242..726935 Replicon chromosome
Accession NZ_CP092533
Organism Escherichia coli strain DS566-1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MKD47_RS03520 Protein ID WP_000415584.1
Coordinates 726242..726538 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MKD47_RS03525 Protein ID WP_000650107.1
Coordinates 726540..726935 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD47_RS03485 (721330) 721330..721644 - 315 WP_000958598.1 putative quinol monooxygenase -
MKD47_RS03490 (721675) 721675..722256 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MKD47_RS03495 (722575) 722575..722907 + 333 WP_000917685.1 DUF2645 family protein -
MKD47_RS03500 (722953) 722953..724302 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MKD47_RS03505 (724299) 724299..724958 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
MKD47_RS03510 (725110) 725110..725502 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MKD47_RS03515 (725555) 725555..726037 + 483 WP_000183505.1 GyrI-like domain-containing protein -
MKD47_RS03520 (726242) 726242..726538 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MKD47_RS03525 (726540) 726540..726935 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MKD47_RS03530 (727068) 727068..728675 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MKD47_RS03535 (728813) 728813..731071 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T236398 WP_000415584.1 NZ_CP092533:726242-726538 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T236398 NZ_LR590480:3017587-3017898 [Bordetella parapertussis]
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAACTGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT236398 WP_000650107.1 NZ_CP092533:726540-726935 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT236398 NZ_LR590480:3017901-3018200 [Bordetella parapertussis]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References